[關(guān)鍵詞]
[摘要]
目的 探討夏荔芪膠囊聯(lián)合琥珀酸索利那新片治療男性腎虛濕熱型膀胱過度活動(dòng)癥(OAB)的臨床療效。方法 選取2023年6月—2024年5月在深圳市中醫(yī)院治療的男性膀胱過度活動(dòng)癥患者80例,采用區(qū)組隨機(jī)化方式分為對照組(40例)和治療組(40例)。對照組患者餐后口服琥珀酸索利那新片,5 mg/次,1次/d。治療組在對照組的基礎(chǔ)上餐后口服夏荔芪膠囊,1.35 mg/次,3次/d。兩組患者療程均為4周。觀察兩組患者臨床療效,比較治療前后兩組患者中醫(yī)癥狀積分,OABSS評分,I-QOL評分和不良反應(yīng)。結(jié)果 治療后,相對于對照組的70.00%,治療組總有效率(87.50%)更高(P<0.05)。治療后,兩組患者中醫(yī)癥狀各項(xiàng)積分和OABSS評分較治療前均明顯減少,而I-QOL評分明顯提升(P<0.05),且治療組中醫(yī)癥狀各項(xiàng)積分、OABSS評分和I-QOL評分明顯好于對照組(P<0.05)。結(jié)論 夏荔芪膠囊聯(lián)合琥珀酸索利那新片治療膀胱過度活動(dòng)癥對于改善患者臨床癥狀、提高生活質(zhì)量和降低不良反應(yīng)發(fā)生率等方面有顯著效果。
[Key word]
[Abstract]
Objective To evaluate the clinical efficacy of Xialiqi Capsules combined with Solifenacin Succinate Tablets in treatment of male overactive bladder of kidney deficiency and damp-heat type. Methods Patients (80 cases) with overactive bladder of kidney deficiency and damp-heat type in Shenzhen Traditional Chinese Medicine Hospital from June 2023 to May 2024 were divided into control (40 cases) and treatment (40 cases) group by block randomization. Patients in the control group were po administered with Solifenacin Succinate Tablets after meals, 5 mg/time, once daily. Patients in the treatment group were po administered with Xialiqi Capsules after meals on the basis of the control group, 1.35 mg/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical evaluations were evaluated, and the TCM symptom scores, overactive bladder symptom score (OABSS), incontinence quality of life (I-QOL) scores and adverse reaction in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 87.50%, which was higher than that of the control group (70.00%), the effective rate of the treatment group was significantly higher (P < 0.05). After treatment, the TCM symptoms scores and the OABSS in two groups were significantly decreased compared with those before treatment, while the I-QOL score was significantly increased (P < 0.05). Moreover, the scores of TCM symptoms, OABSS, and I-QOL in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion The combination therapy utilizing Xialiqi Capsules along with Solifenacin Succinate Tablets can improve the symptoms, promotion the quality of life of the patients and reduce the incidence of adverse reactions.
[中圖分類號]
R983
[基金項(xiàng)目]
中國中醫(yī)科學(xué)院科技創(chuàng)新工程重大攻關(guān)項(xiàng)目(CI2021A02208);深圳市科技計(jì)劃資助項(xiàng)目(JCYJ20220531092201002)