[關(guān)鍵詞]
[摘要]
目的 探討婦科再造膠囊聯(lián)合炔雌醇環(huán)丙孕酮治療月經(jīng)不調(diào)(腎虛證)的有效性、安全性及對性激素和血液流變學(xué)指標(biāo)的影響。方法 納入2023年1~12月于南陽市中心醫(yī)院婦產(chǎn)科就診的月經(jīng)不調(diào)女性患者160例,隨機(jī)分為對照組和治療組,每組各80例。對照組口服炔雌醇環(huán)丙孕酮片,月經(jīng)第5天開始服藥,1片/d。治療組在對照組的基礎(chǔ)上口服婦科再造膠囊,2次/d,6粒/次。21 d為1個(gè)療程,兩組治療3個(gè)療程。觀察兩組患者臨床療效,比較治療前后兩組患者月經(jīng)癥狀量表(MDQ)評分和中醫(yī)證候積分,激素黃體生成素(LH)、雌二醇(E2)和孕酮(P)水平,血液流變學(xué)指標(biāo)血漿黏度(PV)、全血低切黏度(LSWBV)和全血高切黏度(HSWBV)水平。結(jié)果 治療后,治療組總有效率為92.50%,顯著高于對照組的總有效率(81.25%,P<0.05)。治療后,兩組MDQ評分、中醫(yī)證候積分、LH、PV、LSWBV及HSWBV均比治療前顯著降低,而E2和P水平均顯著升高,同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,治療組患者M(jìn)DQ評分、中醫(yī)證候積分、LH、PV、LSWBV及HSWBV均顯著低于對照組,而E2和P水平均顯著升高,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 婦科再造膠囊聯(lián)合炔雌醇環(huán)丙孕酮治療月經(jīng)不調(diào)(腎虛證)的臨床療效顯著,且安全性較高,可能與改善性激素及血液流變學(xué)指標(biāo)等有關(guān)。
[Key word]
[Abstract]
Objective To investigate the efficacy and safety of Fuke Zaizao Capsules combined with ethinylestradiol and cyproterone acetate in treatment of irregular menstruation (kidney deficiency syndrome) and the influence on sex hormones and hemorheology indexes. Methods Patients (160 cases) with irregular menstruation (kidney deficiency syndrome) in Nanyang Central Hospital from January 2023 to December 2023 were randomly divided into control and treatment group, and each group had 80 cases. Patients in the control group were po administered with Ethinylestradiol and Cyproterone Acetate Tablets from the 5th day of menstruation, 1 tablet/d. Patients in the treatment group were po administered with Fuke Zaizao Capsules on the basis of the control group, 6 grains/time, twice daily. 21 days was a course of treatment, and patients in two groups were treated for 3 courses. After treatment, the clinical evaluations were evaluated, and the MDQ scores and TCM syndrome scores, the levels of E2, P and LH, and the hemorheological indexes PV, LSWBV and HSWBV levels in two groups before and after treatment were compared. Results After treatment, the total effective rate in the treatment group was 92.50%, which was significantly higher than that in the control group (81.25%, P < 0.05). After treatment, the MDQ score, TCM syndrome score, LH, PV, LSWBV and HSWBV in two groups were significantly lower than before treatment, while the E2 and P levels were significantly higher, the difference between before and after treatment in the same group was statistically significant (P < 0.05). After treatment, the MDQ score, TCM syndrome score, LH, PV, LSWBV and HSWBV in the treatment group were significantly lower than those in the control group, while the E2 and P levels were significantly higher, the difference between the two groups was statistically significant (P < 0.05). Conclusion Fuke Zaizao Capsules combined with ethinylestradiol andcyproterone acetate in the treatment of irregular menstruation (kidney deficiency syndrome) with a significant clinical efficacy and safety, which may be related to the improvement of sex hormones and hemorheology indexes.
[中圖分類號]
R984
[基金項(xiàng)目]
河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃項(xiàng)目(LHGJ20200525)