骨質(zhì)疏松癥目前已成為全球首要公共衛(wèi)生問題之一，不僅增加患者骨折的風(fēng)險，還給家庭和社會帶來沉重的負(fù)擔(dān)，提高骨質(zhì)疏松癥的防治效果成為廣大醫(yī)師研究的熱點。異補(bǔ)骨脂素是由補(bǔ)骨脂中提取的脂溶性物質(zhì)，可通過促進(jìn)成骨細(xì)胞增殖和分化、抑制破骨細(xì)胞增殖和活性、雙向調(diào)節(jié)骨代謝、促進(jìn)成骨相關(guān)基因的表達(dá)、發(fā)揮雌激素樣活性發(fā)揮抗骨質(zhì)疏松作用。總結(jié)了異補(bǔ)骨脂素抗骨質(zhì)疏松的藥理作用研究進(jìn)展，總結(jié)其作用機(jī)制，為異補(bǔ)骨脂素的臨床應(yīng)用提供參考。

Osteoporosis has become one of the world's top public health issues. It not only increases the risk of fractures in patients, but also brings a heavy burden to families and society. Improving the prevention and treatment of osteoporosis has become a hot topic for many physicians. Isopsoralen is a lipophilic substance extracted from Psoraleae Fructus. Isopsoralen can promote osteoblast proliferation and differentiation, inhibit osteoclasts proliferation and activity, bidirectionally regulate bone metabolism, promote the expression of osteogenic-related genes, and exert estrogen-like activity to exert anti-osteoporosis effects. This article summarizes the research progress on the pharmacological effects of isopsoralen against osteoporosis, summarizes its mechanism of action, and provides reference for the clinical application of isopsoralen.

R965;R982

廣東省基礎(chǔ)與應(yīng)用基礎(chǔ)研究基金項目（2020B1515120052）