肝纖維化是多種慢性肝病必經(jīng)的病理進(jìn)程和病理結(jié)果，最終進(jìn)展為肝硬化。氧化苦參堿是由苦參中提取的生物堿，具有強(qiáng)效抗炎活性，可通過抑制肝星狀細(xì)胞的活力，減輕炎癥反應(yīng)，降低氧化應(yīng)激反應(yīng)，抑制成纖維細(xì)胞活性，抑制Ⅰ型前膠原的沉積，調(diào)節(jié)腸道菌群，抑制細(xì)胞外基質(zhì)的過度沉積，多靶點(diǎn)調(diào)控基因表達(dá)發(fā)揮抗肝纖維化作用。總結(jié)了氧化苦參堿抗肝纖維化的研究，歸納其作用機(jī)制，為氧化苦參堿的臨床應(yīng)用提供思路。

Liver fibrosis is a necessary pathological process and outcome in various chronic liver diseases, ultimately leading to cirrhosis. Oxymatrine is an alkaloid extracted from Sophorae Flavescentis Radix, which has potent anti-inflammatory activity, and can exert anti liver fibrosis effects by inhibiting the activity of hepatic stellate cells, reducing inflammatory responses, lowering oxidative stress responses, suppressing fibroblast activity, inhibiting the deposition of type I procollagen, regulating intestinal flora, inhibiting excessive deposition of extracellular matrix, and multi-target regulation of gene expression. This article summarizes the research on oxymatrine against liver fibrosis, summarizes its mechanism, and provides ideas for the clinical application of oxymatrine.

R965;R975

海南省衛(wèi)生計(jì)生行業(yè)科研項(xiàng)目（19A200135）