目的 探討解毒生肌膏聯(lián)合重組人表皮生長因子凝膠（酵母）治療皮膚燒燙傷的臨床應(yīng)用效果。方法 研究對象為2023年2月—2024年2月于江南大學(xué)附屬醫(yī)院就診的96例皮膚燒燙傷患者，按照隨機(jī)數(shù)字表法將患者分為對照組、治療組，各48例。對照組取重組人表皮生長因子凝膠（酵母）均勻涂于患處，100 cm²創(chuàng)面使用10 g，1次/d；治療組在對照組基礎(chǔ)上使用解毒生肌膏外用攤于紗布上敷患處，0.5 g/cm²皮膚，2次/d?？傊委煰煶虨?8 d。比較兩組臨床療效、創(chuàng)面愈合情況、疼痛程度、生存質(zhì)量、血清炎性因子水平。結(jié)果 治療組的總有效率（100.00%）高于對照組的總有效率（87.50%，P＜0.05）。治療組治療后創(chuàng)面愈合率高于對照組，治療組創(chuàng)面愈合時(shí)間短于對照組（P＜0.05）。治療后，兩組視覺模擬評(píng)分法（VAS）評(píng)分均下降（P＜0.05），且治療組VAS評(píng)分低于對照組（P＜0.05）。治療后，兩組軀體健康領(lǐng)域評(píng)分、心理健康領(lǐng)域評(píng)分、社會(huì)活動(dòng)領(lǐng)域評(píng)分、一般健康狀況領(lǐng)域評(píng)分均較治療前上升（P＜0.05），且治療組各簡明燒傷健康量表（BSHS-A）評(píng)分高于對照組（P＜0.05）。治療后，兩組血清白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）、C反應(yīng)蛋白（CRP）水平較治療前降低（P＜0.05），且治療組血清IL-6、TNF-α、CRP水平均低于對照組（P＜0.05）。結(jié)論 解毒生肌膏聯(lián)合重組人表皮生長因子凝膠（酵母）治療皮膚燒燙傷的效果顯著，可促進(jìn)創(chuàng)面愈合，減輕疼痛，降低機(jī)體炎性因子水平，提高生存質(zhì)量水平。

Objective To explore the clinical application effect of Jiedu Shengji Ointments combined with Recombinant Human Epidermal Growth Factor Gel (Yeast) in treatment of skin burns and scalds.Methods 96 Patients with skin burns and scalds who visited Affiliated Hospital of Jiangnan University from February 2023 to February 2024 were selected and divided into control group and treatment group using random number table method, with 48 cases in each group. The control group patients evenly applied Recombinant Human Epidermal Growth Factor Gel (Yeast) to the affected area, using 10 g on a 100 cm² wound, once daily. The treatment group used Jiedu Shengji Ointments externally spread on gauze on the affected area on the basis of the control group, 0.5 g/cm² skin, twice daily. The total treatment course was 28 days. The clinical efficacy, wound healing, pain level, quality of life, and serum inflammatory factor levels were compared between two groups.Results The total effective rate of the treatment group (100.00%) was higher than that of the control group (87.50%, P < 0.05). The wound healing rate of the treatment group was higher than that of the control group after treatment, but the wound healing time of the treatment group was shorter than that of the control group (P < 0.05). After treatment, the VAS scores of both groups were decreased (P < 0.05), and the VAS score of the treatment group was lower than that of the control group (P < 0.05). After treatment, the scores in the physical health status, mental health status, social activity status, and general health status of both groups were increased (P < 0.05), and the scores of the BSHS-A scores in the treatment group were higher than those in the control group (P < 0.05). After treatment, the serum levels of IL-6, TNF-α, and CRP in both groups were decreased (P < 0.05), and the serum levels of IL-6, TNF-α, and CRP in the treatment group were lower than those in the control group (P < 0.05).Conclusion The combination therapy of Jiedu Shengji Ointments and Recombinant Human Epidermal Growth Factor Gel (Yeast) has a significant effect on skin burns and scalds, which can promote wound healing, relieve pain, reduce the level of inflammatory factors in the body, and improve the quality of life.

R973

無錫市衛(wèi)生健康委科研項(xiàng)目（Q201941）