[關(guān)鍵詞]
[摘要]
肝細(xì)胞癌是一種發(fā)病率高、早期發(fā)病不易察覺、預(yù)后較差的惡性腫瘤。姜黃素是從姜科植物中提取的一種天然的酚類抗氧化劑，具有多種藥理作用，可抑制腫瘤細(xì)胞增殖、誘導(dǎo)腫瘤細(xì)胞凋亡、抑制腫瘤細(xì)胞遷移與侵襲、調(diào)控腫瘤表觀遺傳、抑制腫瘤新血管生成、誘導(dǎo)腫瘤細(xì)胞自噬、延緩或逆轉(zhuǎn)腫瘤耐藥。對(duì)姜黃素抗肝癌的作用機(jī)制進(jìn)行總結(jié)，以期為肝癌的臨床治療提供思路和方法。
[Key word]
[Abstract]
Hepatocellular carcinoma is a highly prevalent malignant neoplasm characterized by its insidious onset and poor prognosis. Curcumin, a natural phenolic antioxidant extracted from Zingiberaceae family, has various pharmacological effects. Curcumin can inhibit tumor cell proliferation, induce tumor cell apoptosis, suppress tumor cell migration and invasion, regulate tumor epigenetics, inhibit tumor angiogenesis, induce tumor cell autophagy, and delay or reverse tumor drug resistance. This article summarizes the mechanism of curcumin against liver cancer, to provide ideas and methods for the clinical treatment of liver cancer.
[中圖分類號(hào)]
R979.1
[基金項(xiàng)目]
國(guó)家自然科學(xué)基金資助項(xiàng)目（81860889）；廣西自然科學(xué)基金項(xiàng)目（2024GXNSFAA010131）；廣西中醫(yī)藥重點(diǎn)研究室建設(shè)項(xiàng)目（桂中醫(yī)藥科教發(fā)[2023]9號(hào)）；廣西（青年）岐黃學(xué)者培養(yǎng)項(xiàng)目（桂中醫(yī)藥科教發(fā)[2024]8號(hào)）
