子宮內(nèi)膜癌是女性生殖系統(tǒng)常見惡性腫瘤，目前臨床對子宮內(nèi)膜癌治療以化療、激素、靶向治療為主。雷公藤甲素是由雷公藤中提取的環(huán)氧二萜內(nèi)酯化合物，可通過抑制腫瘤細(xì)胞增殖、促進(jìn)腫瘤細(xì)胞凋亡、抑制腫瘤細(xì)胞侵襲和轉(zhuǎn)移、抑制腫瘤血管形成、克服化療耐藥性限制子宮內(nèi)膜癌的生長，發(fā)揮有效的抗腫瘤活性?？偨Y(jié)了雷公藤甲素防治子宮內(nèi)膜癌的藥理作用研究進(jìn)展，為雷公藤甲素臨床防治子宮內(nèi)膜癌提供參考。

Endometrial cancer is a common malignant tumor of the female reproductive system. At present, the clinical treatment of endometrial cancer mainly includes chemotherapy, steroids, and targeted therapy. Triptolide is an epoxy diterpenoid lactone extracted from Tripterygii Radix et Rhizoma, and can limit the growth of endometrial cancer and exert effective anti-tumor activity by inhibiting tumor cell proliferation, promoting tumor cell apoptosis, inhibiting tumor cell invasion and metastasis, inhibiting tumor angiogenesis, overcoming chemotherapy resistance. This article summarizes the pharmacological research progress of triptolide in prevention and treatment of endometrial cancer, providing reference for the clinical prevention and treatment of endometrial cancer with triptolide.

R979.1

江蘇省衛(wèi)生健康委科研項(xiàng)目（H2023113）