[關(guān)鍵詞]
[摘要]
目的 探討地高辛片聯(lián)合福辛普利片治療老年高血壓心力衰竭的臨床療效。方法 選取2016年9月—2017年10月武漢市第五醫(yī)院心內(nèi)科收治的老年高血壓心力衰竭患者82例,依據(jù)治療方法的不同分為對照組和治療組,每組各41例。對照組口服福辛普利鈉片,初始劑量為10 mg/次,依據(jù)患者耐受性、血壓、心率等情況逐漸增加劑量至40 mg/次,1次/d。治療組在對照組治療的基礎(chǔ)上口服地高辛片,0.125~0.25 mg/次,1次/d。兩組患者均連續(xù)治療30 d。觀察兩組的臨床療效,比較兩組的心功能指標(biāo)。結(jié)果 治療后,對照組和治療組的總有效率分別為78.05%、92.68%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組左心室舒張末期內(nèi)徑(LVEDD)、左心室收縮末期內(nèi)徑(LVESD)顯著降低,左心室射血分?jǐn)?shù)(LVEF)顯著升高,同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組心功能指標(biāo)明顯優(yōu)于對照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 地高辛片聯(lián)合福辛普利片治療老年高血壓心力衰竭具有較好的臨床療效,可改善患者心功能指標(biāo),安全性較好,具有一定的臨床推廣應(yīng)用價(jià)值。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Digoxin Tablets combined with Fosinopril Sodium Tablets in treatment of elderly hypertensive patients with heart failure. Methods Elderly hypertensive patients (82 cases) with heart failure in the Fifth Hospital of Wuhan from September 2016 to October 2017 were randomly divided into control and treatment groups, and each group had 41 cases. Patients in the control group were po administered with Fosinopril Sodium Tablets, starting dosage 10 mg/time, gradually increased the dosage to 40 mg/time according to patient tolerance, blood pressure, heart rate and so on, once daily. Patients in the treatment group were po administered with Digoxin Tablets on the basis of the control group, 0.125 - 0.25 mg/time, once daily. Patients in two groups were treated for 30 d. After treatment, the clinical efficacies were evaluated, and the cardiac function indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.05% and 92.68%, respectively, and there was difference between two groups (P<0.05). After treatment, the LVEDD and LVESD in two groups were significantly decreased, but the LVEF in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the cardiac function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Digoxin Tablets combined with Fosinopril Sodium Tablets has clinical curative effect in treatment of elderly hypertensive patients with heart failure, can improve the cardiac function indexes, with good safety, which has a certain clinical application value.
[中圖分類號(hào)]
[基金項(xiàng)目]