目的 探討達立通顆粒聯(lián)合法莫替丁治療胃食管反流病的臨床療效。方法 選取2017年5月—2018年5月在洪湖市中醫(yī)醫(yī)院治療的胃食管反流病患者82例，根據(jù)用藥差別分為對照組（41例）和治療組（41例）。對照組口服法莫替丁片，20 mg/次，2次/d；治療組在對照組基礎(chǔ)上口服達立通顆粒，6 g/次，3次/d。兩組均治療8周。觀察兩組患者臨床療效，同時比較治療前后兩組患者GerdQ評分、SF-36評分、食管測壓和24 h食管pH監(jiān)測情況。結(jié)果 治療后，對照組臨床有效率為80.49%，顯著低于治療組的97.56%，兩組比較差異具有統(tǒng)計學(xué)意義。治療后，兩組GerdQ評分顯著降低（P<0.05），SF-36評分顯著升高（P<0.05），且治療組GerdQ和SF-36評分明顯好于對照組（P<0.05）。治療后，兩組上食管括約肌（UES）靜息壓、下食管括約?。↙ES）靜息壓、蠕動波傳導(dǎo)速度、濕咽成功率明顯升高（P<0.05），且治療組上述食管測壓指標明顯高于對照組（P<0.05）。治療后，兩組24 h食管酸反流總次數(shù)、酸反流大于5 min次數(shù)、總計pH<4百分比、最長反流時間均顯著降低（P<0.05），且治療組這些指標明顯低于對照組（P<0.05）。結(jié)論 達立通顆粒聯(lián)合法莫替丁治療胃食管反流病可有效改善患者臨床癥狀，有利于食管動力改善，降低酸反流，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical efficacy of Dalitong Granules combined with famotidine in treatment of gastroesophageal reflux disease. Methods Patients (82 cases) with gastroesophageal reflux disease in Honghu Hospital of Traditional Chinese Medicine from May 2017 to May 2018 were divided into control (41 cases) and treatment (41 cases) groups based on different treatments. Patients in the control group were po administered with Famotidine Tablets, 20 mg/time, twice daily. Patients in the treatment group were po administered with Dalitong Granules on the basis of the control group, 6 g/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and GerdQ scores, SF-36 scores, esophageal manometry and 24 h esophageal pH monitoring in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.49%, which was significantly lower than 97.56% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the GerdQ scores in two groups were significantly decreased (P<0.05), but SF-36 scores were significantly increased (P<0.05), and the GerdQ and SF-36 scores in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the resting pressure of UES and LES, creeping wave conduction velocity, and success rate of wet pharynx in two groups was significantly increased (P<0.05), and the esophageal manometry in the treatment group were significantly higher than that in the control group (P<0.05). After treatment, the total frequency of 24 h esophageal acid reflux, the frequency of acid reflux time >5 min, total pH<4 ratio, and maximum acid reflux time in two groups was significantly decreased (P<0.05), and these indexes in the treatment group were significantly lower than that in the control group (P<0.05). Conclusion Dalitong Granules combined with famotidine in treatment of gastroesophageal reflux disease can effectively improve the clinical symptoms and the esophageal motility, reduce acid reflux, which has a certain clinical application value.