目的 探討葆宮止血顆粒聯(lián)合甲羥孕酮治療藥物流產(chǎn)后持續(xù)陰道出血的臨床療效。方法 選取2017年1月—2018年6月新鄉(xiāng)醫(yī)學(xué)院第一附屬醫(yī)院收治的122例藥物流產(chǎn)后持續(xù)陰道出血患者，隨機分為對照組和治療組，每組各61例。對照組口服醋酸甲羥孕酮片，10 mg/次，1次/d。治療組在對照組治療基礎(chǔ)上口服葆宮止血顆粒，1袋/次，3次/d。兩組均治療7 d。觀察兩組的臨床療效，比較兩組出血控制、月經(jīng)恢復(fù)、宮腔組織殘留情況。比較兩組治療前后子宮內(nèi)膜厚度、孕酮（P）、人絨毛膜促性腺激素（HCG）的變化情況。結(jié)果 治療后，對照組和治療組的總有效率分別是83.6%、95.1%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，治療組陰道出血持續(xù)時間、月經(jīng)復(fù)潮時間均顯著短于對照組，且治療組陰道出血量、月經(jīng)復(fù)潮量均少于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療組宮內(nèi)組織殘留率為8.2%顯著低于對照組21.3%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）；治療后，兩組子宮內(nèi)膜厚度均顯著增加，血清P、HCG水平均顯著降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；治療后，治療組子宮內(nèi)膜厚度顯著高于對照組，治療組血清P、HCG水平顯著低于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，對照組和治療組的并發(fā)癥發(fā)生率分別是19.7%、6.6%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 葆宮止血顆粒聯(lián)合甲羥孕酮治療藥物流產(chǎn)后持續(xù)陰道出血具有較好的臨床療效，能有效控制出血，促進(jìn)子宮內(nèi)膜修復(fù)及宮內(nèi)殘留組織的排出，減少并發(fā)癥，促進(jìn)月經(jīng)復(fù)潮，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Baogong Zhixue Granules combined with medroxyprogesterone in treatment of persistent vaginal bleeding after drug abortion. Methods 122 Patients with persistent vaginal bleeding after drug abortion in the First Affiliated Hospital of Xinxiang Medical University from January 2017 to June 2018 were randomly divided into control (61 cases) and treatment (61 cases) groups. Patients in the control group were po administered with Medroxyprogesterone Acetate Tablets, 10 mg/time, once daily. Patients in the treatment group were po administered with Baogong Zhixue Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the situations of bleeding, menstrual recovery, uterine cavity tissue residue in two groups were compared. The changes of endometrial thickness, progesterone (P) and human chorionic gonadotropin (HCG) before and after treatment in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment group were 83.6% and 95.1%, and there were differences between two groups (P<0.05). After treatment, the duration of vaginal bleeding and menstrual rehydration in the treatment group were significantly shorter than those in the control group, and the amount of vaginal bleeding and menstrual rehydration in the treatment group was less than that in the control group, and there were differences between two groups (P<0.05).The intrauterine tissue residual rate of the treatment group was 8.2%, which was significantly lower than that of the control group (21.3%), and there were differences between two groups (P<0.05). After treatment, endometrium thickness in two groups was significantly increased, but P and HCG were significantly decreased, and there were differences in the same group (P<0.05). After treatment, endometrium thickness in the treatment group was significantly higher than that of the control group, but P and HCG were significantly lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, the complication rate in the control and treatment group was 19.7% and 6.6%, and there were differences between two groups (P<0.05).Conclusion Baogong Zhixue Granules combined with medroxyprogesterone has significant clinical effect in treatment of persistent vaginal bleeding after drug abortion, and can effectively control bleeding, also can promote endometrial repair and discharge of intrauterine residual tissue, and reduce complications, and promote menstruation, which has a certain clinical application value.