目的 探討?yīng)氁晃赌z囊聯(lián)合甲硝唑治療慢性牙齦炎的臨床效果。方法 選取北京懷柔醫(yī)院2016年2月—2017年10月收治的慢性牙齦炎患者112例，隨機(jī)分成對(duì)照組和治療組，每組各56例。對(duì)照組患者將甲硝唑口頰片置于牙齦與齦溝處含化，1片/次，3次/d。治療組在對(duì)照組的基礎(chǔ)上口服獨(dú)一味膠囊，3粒/次，3次/d。兩組患者連續(xù)治療14 d。觀察兩組患者臨床療效，同時(shí)比較治療前后兩組患者齦溝出血指數(shù)（SBI）、菌斑指數(shù)（PLI）、齦溝液腫瘤壞死因子-α（TNF-α）水平。結(jié)果 治療后，對(duì)照組和治療組臨床有效率分別為80.36%和94.64%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療7、14 d后，兩組患者SBI、PLI指數(shù)和齦溝液TNF-α水平均比治療前顯著降低，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組治療7、14 d后SBI、PLI指數(shù)和齦溝液TNF-α水平比同時(shí)期對(duì)照組均明顯降低，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 獨(dú)一味膠囊聯(lián)合甲硝唑治療慢性牙齦炎療效顯著，且無(wú)明顯不良反應(yīng)，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical effect of Duyiwei Capsules combined with metronidazole in treatment of chronic gingivitis. Methods Patients (112 cases) with chronic gingivitis in Beijing Huairou Hospital from February 2016 to October 2017 were randomly divided into control and treatment groups, and each had 56 cases. Patients in the control group were buccally administered with Metronidazole Buccal Tablets in gingiva and gingival sulcus, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Duyiwei Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the SBI, PLI indexes, and TNF-α levels in gingival crevicular fluid in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 80.36% and 94.64% respectively, and there were differences between two groups (P<0.05). After treatment for 7, 14 d, the SBI, PLI indexes and TNF-α levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment for 7, 14 d, the SBI, PLI indexes and TNF-α levels in the treatment group were significantly lower than those in the control group of the same period, with significant difference between two groups (P<0.05). Conclusion Duyiwei Capsules combined with metronidazole in treatment of chronic gingivitis has obvious curative effect without obvious adverse reaction, which has a certain clinical application value.