接頭蛋白或支架蛋白可以介導(dǎo)蛋白-蛋白之間的相互作用，并促進(jìn)蛋白復(fù)合物的形成。Gab2作為中介分子，通過(guò)招募受體酪氨酸激酶等膜受體與其下游的效應(yīng)蛋白如SHP2、P13K的p85亞基，PLCγ、CRK、SHC和SHIP的結(jié)合來(lái)實(shí)現(xiàn)信號(hào)的傳遞。近年來(lái)，由于Gab2支架蛋白在信號(hào)轉(zhuǎn)導(dǎo)過(guò)程中發(fā)揮著重要的作用，使得其在人類(lèi)癌癥特別是白血病、乳腺癌、卵巢癌及黑色素瘤中的角色備受關(guān)注。Gab2主要參與介導(dǎo)SHP2/RAS/ERK和PI3K/AKT兩條經(jīng)典的信號(hào)通路。綜述Gab2的結(jié)構(gòu)與功能，調(diào)解的蛋白，在癌癥中的作用以及其作為藥物治療靶點(diǎn)的潛力。

Adaptor or scaffolding proteins mediate protein-protein interactions that drive the formation of protein complexes. Gab2 scaffolding protein is an intermediary molecule that links plasma membrane receptor signaling including receptor tyrosine kinases with the downstream effectors such as SHP2, p85 subunit of PI3K, PLCγ, CRK, SHC, and SHIP. Although well described in signal transduction, the role of Gab2 scaffolding protein in cancer has recently been emerging especially in leukemia, breast and ovarian cancer, and melanoma. Gab2 is essential for mediating the two major signal transduction pathways in cancer, the PI3K-AKT and ERK signaling pathways. This review focuses on the structure and function of Gab2, its regulatory proteins, emerging role in cancer, and potential as a therapeutic target.