目的：為骨質(zhì)疏松癥的預(yù)防與治療提供循證醫(yī)學(xué)證據(jù)。方法：循證檢索PubMed的Clinical Queries，獲取骨質(zhì)疏松癥預(yù)防與治療相關(guān)文獻，將檢索所得文獻有選擇性的閱讀消化提煉，獲得可信循證醫(yī)學(xué)證據(jù)。結(jié)果：不同的檢索策略分別獲得文獻20 346篇、2 192篇和454篇。文獻分析表明，原發(fā)性骨質(zhì)疏松癥可使用每月po一次伊班膦酸鹽來預(yù)防，繼發(fā)性骨質(zhì)疏松癥可使用每三個月iv一次氯膦酸鹽來預(yù)防，也可采用靜脈滴注唑來膦酸5 mg或po 5 mg利塞膦酸鹽。飲茶可作為非藥物治療預(yù)防骨質(zhì)疏松的方法。飲食治療要多食入一些含鈣、磷、維生素及蛋白質(zhì)豐富的食品，以彌補體內(nèi)與骨代謝有關(guān)的物質(zhì)的不足。藥物治療可選用補充鈣和維生素D鈣、降鈣素、二膦酸鹽。還可采用雌激素補充療法、物理療法等。結(jié)論：骨質(zhì)疏松癥的防治可采用飲食、運動、物理和藥物等綜合療法。

Objective: To provide the evidence-based medicine used in the prevention and treatment for osteoporosis. Methods: All the studies on osteoporosis were searched in Clinical Queries of Pubmed with the theme “osteoporosis” and identified to obtain the reliable evidence-based medicine. Results: There were 20 346, 2 192, and 454 studies on osteoporosis were found by different search strategies, respectively. The results indicated that primary osteoporosis can be prevented with po ibandronate once a month; secondary osteoporosis can be prevented with iv clodronateonce three months, or iv zoledronic acid (5 mg) or po risedronate (5 mg). Drinking tea is a choice in preventing and treating of osteoporosis. Dietary rich in calcium, phosphonium, vitamin, and protein can be used as the supplement of element lossing in bone metabolism. Calcium preparation, calcitonin, bisphosphonates, and estrogen can be used in the treatment of osteoporosis. Physical exercise therapy and physiotherapy can also be taken in the treatment of osteoporosis. Conclusion: Osteoporosis can be prevented and treated with diet therapy, physical exercise therapy, and physiotherapy in combination with medicine therapy as well.