目的 觀察黃芪桂枝五物湯（浸膏）長(zhǎng)期用藥對(duì)大鼠所產(chǎn)生的毒性反應(yīng)。方法 連續(xù)給藥13周，試驗(yàn)期間對(duì)大鼠的外觀、行為、體質(zhì)量以及攝食等各項(xiàng)指標(biāo)進(jìn)行觀察檢測(cè)，并分別于給藥結(jié)束和恢復(fù)期結(jié)束進(jìn)行血液學(xué)、血液生化學(xué)以及病理組織學(xué)檢查。結(jié)果 在黃芪桂枝五物湯（浸膏）給藥期間、給藥結(jié)束后以及恢復(fù)期，大鼠體質(zhì)量、攝食、血液學(xué)、血液生化學(xué)和病理組織學(xué)等均未見(jiàn)毒理學(xué)意義的異常改變。結(jié)論 在本實(shí)驗(yàn)條件下，黃芪桂枝五物湯（浸膏）24.0 g/(kg·d)（相當(dāng)于臨床擬用日劑量109倍）為無(wú)毒反應(yīng)劑量，表明該藥物具有相當(dāng)大的安全范圍。

Objective To observe the toxic reaction of Huangqi Guizhi Wuwu Decoction on rats by long-term drug toxicity. Methods During the experiment, certain index of appearance, behavior, weight, and food intake were detected after successive administration for 13 weeks, and then, the hematology, blood-biochemics, and pathohistology in end administration period and recovery period were examined, respectively. Results Huangqi Guizhi Wuwu Decoction has no toxicological abnormal changes of weight, food intake, hematology, blood-biochemics, and pathohistology during administration end administration, and convalescent periods. Conclusion In the situation of this experiment, 24.0 g/(kg·d) (109 times dosage as much as that of clinical daily dose) of Huangqi Guizhi Wuwu Decoction is the non-toxic reaction dosage, which indicates that the drug has a sizable margin of safety.