[關(guān)鍵詞]
[摘要]
中藥藥動學(xué)研究是中藥現(xiàn)代化研究鏈條的重要組成部分,在創(chuàng)新中藥及現(xiàn)代復(fù)方中藥研發(fā)中發(fā)揮著極其重要的作用,但目前尚缺乏符合中藥自身特點(diǎn)的藥動學(xué)研究方法。概述現(xiàn)有中藥藥動學(xué)研究現(xiàn)狀,提出了中藥復(fù)方“總量”藥動學(xué)的概念,以期能夠起到拋磚引玉的作用,共同促進(jìn)中藥藥動學(xué)研究水平的提高。
[Key word]
[Abstract]
The pharmacokinetic study on Chinese materia medica (CMM) is an inalienable part of the chain in CMM modernization and plays an important role in the research and development of CMM novel drug and modern CMM formulae. However, nowadays the researching method and system that are consistent with the specific characteristics of CMM, i.e., multiple-components and targets, is still lacking. This review makes a brief summary of our recent developments on the pharmacokinetic exploration of CMMs. A tentative idea about the “total amount” pharmacokinetics of CMM has been proposed in order to promote its pharmacokinetic development.
[中圖分類號]
[基金項(xiàng)目]
“重大新藥創(chuàng)制專項(xiàng)”中藥復(fù)方釋藥系統(tǒng)技術(shù)平臺項(xiàng)目(2009ZX09310-005);“十一五”科技支撐計(jì)劃項(xiàng)目(2006BA109B08-01);江西省衛(wèi)生廳中醫(yī)藥科研項(xiàng)目(2009A061,2009A059)