目的 研究受熱條件下綠原酸的熱穩(wěn)定性、分解動力學(xué)和貯存期。方法 利用TG-DTG技術(shù)測得綠原酸在氮氣氣氛中不同升溫速率（β）下的熱分解曲線，協(xié)同使用Achar法、Coats-Redfern法、Kissinger法和Ozawa法等4種方法進(jìn)行動力學(xué)處理，根據(jù)熱分解的表觀活化能（E_α）和指前因子（A）計算推斷綠原酸的貯存期。結(jié)果 隨著升溫速率的提高，綠原酸的熱分解溫度逐漸升高；綠原酸三步熱分解的機制依次是三維擴散、二維擴散和化學(xué)反應(yīng)控制，對應(yīng)的函數(shù)名稱是Zhuralev-Lesokin-Tempelman方程、Janer方程和反應(yīng)級數(shù)方程；根據(jù)第一步熱分解的E_α和A推斷，在室溫（25 ℃）下，綠原酸的貯存期為1.5～2年。結(jié)論 4種熱分解動力學(xué)方法相互驗證，獲得了綠原酸的熱分解動力學(xué)方程，由動力學(xué)參數(shù)求得綠原酸的貯存期，可以為目前大量含綠原酸藥品的質(zhì)量監(jiān)控提供依據(jù)。

Objective To study the thermal stability, decomposition kinetics, and shelflife of chlorogenic acid under the heat condition. Methods Thermal decomposing curves of chlorogenic acid in different heating speeds were obtained in the nitrogen atmosphere by TG-DTG techniques. Four thermal analysis kinetic methods (Achar, Coats-Redfern, Kissinger, and Ozawa) were used to speculate the probable mechanism of thermal decomposing reaction and the kinetic parameters. The shelflife of chlorogenic acid at room temperature (25 ℃) was calculated by the kinetic parameters of the first stage. Results With the improvement of the heating rate, thermal decomposing tempreture of chlorogenic acid rose. The most probable kinetic mechanisms of the three-stage thermal decomposition were three-dimensional diffusion, two-dimensional diffusion, and chemical reaction, and the corresponding mechanisms followed Zhuralev-Lesokin-Tempelman Equation, Jander Equation, and Reaction Order, respectively. The shelflife of chlorogenic acid at room temperature was about 1.5—2 years. Conclusion With deducing the equation of decomposition kinetics, four thermal analysis kinetic methods verified each other. The shelflife of chlorogenic acid could be used as evaluation method, in order to provide reference for the quality control of the related drug contained chlorogenic acid.

國家科技部項目（2009D20110440）；湖南省自然科學(xué)基金資助項目（10JJ6024）；湖南省科技廳項目（2009FJ3045）；湖南省高?！傲之a(chǎn)資源化學(xué)與林化產(chǎn)品開發(fā)”科技創(chuàng)新團(tuán)隊支持計劃（湘教通（2010）212號）