目的 研究雷公藤內(nèi)酯醇生物貼中雷公藤內(nèi)酯醇在不同條件下的穩(wěn)定性。方法 通過影響因素試驗、加速試驗、長期留樣試驗，采用高效液相色譜法，測定雷公藤內(nèi)酯醇，考察雷公藤內(nèi)酯醇生物貼的穩(wěn)定性。結(jié)果 經(jīng)過光照、升溫、加濕、加速等試驗，雷公藤內(nèi)酯醇生物貼中的雷公藤內(nèi)酯醇的量變化不大。結(jié)論 雷公藤內(nèi)酯醇生物貼在市售包裝及貯藏條件下，質(zhì)量穩(wěn)定。

Objective To study the stability of Triplolide Biological Patches (LTBP). Methods Triplolide content was determinated by HPLC method through strengthen test, accelerated test, and long-term restained sample testing. And the stability of LTBP was investigated. Results Triptolide was relatively stable due to light, temperature, humidity, accelerated testing, and long-term testing. Conclusion The results show that LTBP could be relatively stable in the commercial packaging and storage condition in market.

福建省科技重大專項（2009YZ0001-1-3）；福建省醫(yī)學(xué)創(chuàng)新項目（2009-CX-16）；福建省省屬公益類科研院所基本科研專項（2011R1034-3）