喹諾酮類抗菌藥抗菌譜廣，在臨床上廣泛應(yīng)用于各種感染的治療。喹諾酮類藥物可通過(guò)阻斷拓?fù)涿傅纳砉δ芾^而干擾細(xì)菌的復(fù)制，從而起到抗菌的作用。也正是由于其廣泛應(yīng)用，近年來(lái)此類藥物的耐藥現(xiàn)象嚴(yán)重，且機(jī)制多樣。綜述了喹諾酮類藥物的作用機(jī)制、耐藥機(jī)制及其研究進(jìn)展。

Quinolones have potential and broad antimicrobial activity on gram-positive and -negative bacteria in clinic, respectively. They could interfere the duplication of bacteria by blocking the physiologic function of DNA gyrase and DNA topoisomerase IV. So quinolones have been used worldwide against a variety of infections. As a result of their frequent use, bacterial resistance to quinolones has gradually developed and limited their therapeutic efficacy in infections. This article reviews the antibacterial and resistance mechanisms of quinolone based on the recent research advances.

江蘇省省級(jí)科技創(chuàng)新與成果轉(zhuǎn)化專項(xiàng)引導(dǎo)資金項(xiàng)目（BE2008672）