目的 評價SD孕鼠在致畸敏感期（懷孕第6～15天）ig給予坤泰膠囊溶液對SD大鼠的母體毒性、胚胎-胎仔毒性和致畸性。方法 雌性SD大鼠低、中、高劑量組在懷孕第6～15天內(nèi)分別ig給予2.5、5、10 g/(kg?d) 坤泰膠囊成品粉溶液，對照組給予雙蒸水。試驗期內(nèi)每天觀察動物的一般情況和臨床毒性表現(xiàn)；記錄孕鼠的體質(zhì)量；在懷孕第20天進(jìn)行剖腹檢查，摘取卵巢和子宮，觀察黃體數(shù)、著床數(shù)、胚胎生存及死亡情況、生存胎仔的外觀、性別、體質(zhì)量、骨骼及臟器發(fā)育等指標(biāo)。結(jié)果 孕鼠及胚胎、胎仔發(fā)育的上述各觀察指標(biāo)未見明顯異常，與對照組比較無顯著差異。結(jié)論 在本實驗條件下，坤泰膠囊成品粉未見明顯的母體毒性與胚胎和胎兒發(fā)育毒性。

Objective To evaluate the matrix toxicity, embryo-fetal toxicity, and teratogenicity of ig administration with Kuntai Capsule powder on SD rats in sensitive period to teratogenic agent (day 6―15 of pregnancy). Methods Female rats were administrated with Kuntai Capsule powder solution [2.5, 5, 10 g/(kg?d)] at day 6―15 of pregnancy, while the rats in control group were given double distilled water. In the trial period, general conditions and clinical toxicity performance of the animals were observed daily, and body weight of rats was recorded. SD rats were sacrificed at day 20 after pregnancy. The luteal number, nidation sites, embryo survival and death, the appearance, sex, weight, bone and organ development indicators of survival fetus were observed. Results There were no statistical significance between Kuntai Capsule group and control group in above indexes. Conclusion Kuntai Capsule does not have obvious toxicity on embryo and fetus of rats under the conditions in this paper.