目的 研究10種常用平喘中藥桑白皮、枇杷葉、百部、馬兜鈴、紫菀、款冬花、苦杏仁、蘇子、葶藶子、銀杏葉提取物對磷酸二酯酶4（PDE4）的抑制作用。方法 分別采用水煎煮、95%乙醇回流提取法提取藥材，采用放射性³H標記液體閃爍計數(shù)法檢測提取物對靶標PDE4的抑制活性。結(jié)果 10種平喘中藥的水提物、95%乙醇提取物均顯示一定的抑制PDE4活性?？傮w而言，平喘中藥95%乙醇提取物對PDE4抑制活性高于水提取物。相同濃度下，桑白皮、枇杷葉、款冬花、馬兜鈴活性較高。結(jié)論 平喘類中藥對PDE4靶標具有一定的抑制作用，可能與其平喘作用相關(guān)。

Objective To study the inhibition of ten common anti-asthma traditional Chinese medicines (TCMs) towards phosphodiesterase 4 (PDE4). Methods The TCMs were extracted with boiling water and 95% ethanol reflux, respectively. The inhibition against PDE4 was carried out by radioactive ³H liquid scintillation counting method. Results Both water extracts and ethanol extracts exhibited obvious inhibition against PDE4. In general, the ethanol extracts of ten TCMs showed more potent activities than those of water extracts. At the same concentration, Mori Cortex, Eriobotryae Folium, Farfarae Flos, and Aristolochiae Fructus exhibited obvious activities. Conclusion The common anti-asthma TCMs exhibit obvious inhibition towards PDE4, which may be relative to their treatment of relieving asthma.

國家自然科學基金資助項目（21103234）；教育部留學回國人員啟動基金（2008[290]）；廣東自然科學基金團隊項目（S2011030003190）；中山大學青年教師重點培育計劃（11ykzd05）