目的 探討還陽(yáng)參醇提物對(duì)實(shí)驗(yàn)動(dòng)物的止咳、祛痰、平喘及抗炎作用。方法 分別采用氨水引咳法、氣管酚紅排泄法、組織胺致喘息法觀察還陽(yáng)參醇提物的止咳、祛痰、平喘作用；采用二甲苯致小鼠耳腫脹和蛋清致大鼠足趾腫脹法觀察還陽(yáng)參醇提物抗急性炎癥的作用；氣管內(nèi)注入脂多糖法建立大鼠慢性支氣管炎模型，觀察受試物對(duì)模型大鼠肺組織的病理學(xué)改變。結(jié)果 還陽(yáng)參醇提物能顯著減少小鼠的咳嗽次數(shù)、增加小鼠氣道酚紅排泄量、延長(zhǎng)組織胺所致豚鼠喘息的潛伏期、可減輕蛋清所致的大鼠足趾腫脹度，與對(duì)照組比較差異具有顯著性（P＜0.05或0.01）；還陽(yáng)參醇提物能減輕慢性支氣管炎大鼠黏膜上皮細(xì)胞的壞死和脫落，抑制黏膜層和黏膜下層炎性細(xì)胞浸潤(rùn)。結(jié)論 還陽(yáng)參醇提物有明確的止咳、祛痰、平喘及抗炎作用，對(duì)慢性支氣管炎大鼠模型的支氣管黏膜有保護(hù)作用。

Objective To identify the effects of the alcohol extracts from Crepis turczaniowii (AECT), such as antitussive, expectorant, anti-asthma, and anti-inflammation, on the experimental animals. Methods The cough models of mice were established by ammonia liquor, Phenol Red excretion, and histamine; The acute inflammation models of mice were made by xylene and albumen; The models of chronic bronchitis of rats were made by intratracheal instillation of lipopolysaccharide to observe the lung pathematology. Results AECT could reduce the cough frequency of mice, increase the excretion of phenol red, prolong the latency of asthma induced by histamine, reduce the paw edema extent of rats induce by albumen, compared with the control groups (P < 0.05, 0.01). The histopathological examination revealed AECT could reduce the mortification and desquamation of mucosal epithelial cells in rats with chronic bronchitis and inhibited the mucous and submucosa infiltration of inflammatory cells. Conclusion AECT have the antitussive, expectorant, anti-asthma, and anti-inflammatory effects and could protect the bronchial mucosa of rats with chronic bronchitis.

山西省科技攻關(guān)項(xiàng)目（20120313015-1）；太原市科技項(xiàng)目（12024730）