[關(guān)鍵詞]
[摘要]
目的 考察參芝通絡(luò)膠囊對大鼠的長期毒性,為臨床用藥提供依據(jù)。方法 SD大鼠隨機(jī)分為對照組和參芝通絡(luò)膠囊高、中、低劑量組(4、2、1 g/kg)。ig給藥13周,除觀察一般狀況外,檢測體質(zhì)量、血液學(xué)指標(biāo)、血液生化指標(biāo),解剖計(jì)算內(nèi)臟系數(shù)并進(jìn)行病理組織學(xué)檢查。剩余大鼠停止給藥,恢復(fù)2周后進(jìn)行上述相同指標(biāo)檢測。結(jié)果 參芝通絡(luò)膠囊各劑量組對大鼠一般狀況、體質(zhì)量、血液學(xué)指標(biāo)、血液生化指標(biāo)、內(nèi)臟系數(shù)和病理組織學(xué)無明顯影響,恢復(fù)期大鼠上述各指標(biāo)與對照組比較無明顯差異。結(jié)論 在確定的臨床使用劑量下,參芝通絡(luò)膠囊長期服用無明顯毒性。
[Key word]
[Abstract]
Objective To observe the long term toxicity in rats of Shenzhi Tongluo Capsule (STC) and to provide the science foundation for clinical administration. Methods Sprague-Dawley rats were randomly divided into four experimental groups: control, high-, mid-, and low-dose STC (4, 2, and 1 g/kg) groups , and ig administered continuously for 13 weeks. The general conditions were observed and the related indexes were detected, such as body weight, hematological indexes, and blood biochemical indexes. The rats were dissected, the visceral coefficients of body was calculated and the histopathologic examination was performed. The administration to the remaining rats was stopped for recovering for two weeks. The recovery conditions of rats were observed and the above indexes were detected. Results There was no significant effect of STC at different doses on the general conditions, body weight, hematological and blood biochemical indexes, the visceral coefficients of body, and histopathologic examination. There was no obvious difference in the above indexes of recovered rats compared with the control group. Conclusion STC in certain clinical dose has no toxicity for long term use.
[中圖分類號(hào)]
[基金項(xiàng)目]