目的 評價雄黃注射液注射給藥的安全性。方法 利用小鼠對雄黃注射液進(jìn)行異常毒性、急性毒性實(shí)驗，鱟試劑法檢測內(nèi)毒素，利用家兔進(jìn)行體外溶血實(shí)驗。結(jié)果 雄黃注射液異常毒性實(shí)驗和急性毒性實(shí)驗均未見小鼠死亡，且飲食、行為、運(yùn)動等功能均正常。鱟試劑檢查細(xì)菌內(nèi)毒素結(jié)果呈陰性，對家兔紅細(xì)胞無溶血和凝集作用。結(jié)論 在實(shí)驗條件下雄黃注射液安全性良好。

Objective To evaluate the safety of Realgar Injection (RI). Methods The abnormal toxicity test and acute toxicity test were performed in mice, endotoxin was determined by tachypleus amebocyte lysate method, and hemolysis test was performed in vitro using rabbit blood. Results In the abnormal toxicity test and acute toxicity test there were no dead of mice, and their functions of diet, behavior, and moving were normal. The result of tachypleus amebocyte lysate test was negative and there was no hemolysis and agglutination reaction in vitro. Conclusion The safety of RI used as the clinical injection is good.

黑龍江省教育廳科學(xué)技術(shù)研究項目（12511361，12511362）；黑龍江省青年科學(xué)基金項目（QC2009C115）；黑龍江八一農(nóng)墾大學(xué)科研啟動基金（B2011-13）