目的 觀察靜脈注射三乙醇胺后Beagle犬的組織病理學(xué)改變及其可逆性。方法 Beagle犬12只，分為對照組和150 mg/kg劑量組，連續(xù)給藥30 d和恢復(fù)4周后，分別進行大體解剖和組織病理學(xué)檢查。結(jié)果 連續(xù)給藥30 d，Beagle犬出現(xiàn)肝細胞變性、壞死，及肝竇擴張，網(wǎng)狀纖維蛋白樣物質(zhì)沉積；腎臟髓質(zhì)和皮髓交界處腎小管上皮細胞變性；脾臟、淋巴結(jié)和腸黏膜相關(guān)淋巴組織內(nèi)淋巴濾泡數(shù)量增多，生發(fā)中心增大，脾小體帽區(qū)局灶性壞死，其中雌性動物肝臟、脾臟病變程度較雄性嚴重。經(jīng)過4周恢復(fù)，肝臟、脾臟、腎臟、淋巴結(jié)、腸黏膜相關(guān)淋巴組織病變恢復(fù)不明顯。結(jié)論 靜脈注射一定劑量的三乙醇胺，可能對肝臟、腎臟、脾臟、淋巴結(jié)以及腸黏膜相關(guān)淋巴組織有一定的損傷作用。

Objective Histopathology change of Beagle dog and its recoverability are observed after trolamine iv. Methods Twelve Beagle dogs are divided into control group and 150 mg/kg dosage group, gross anatomy and Histopathology observation are put into practice after the continuous administration for 30 days and the recovery for 4 weeks. Results Some tissue structure of Beagle dogs via 30 d successive administration, such as liver, kidney, spleen, lymph node and intestinal mucosa-related lymphatic tissue, are changed.Hepatocyte degeneration and necrosis, expansion of hepatic sinus and deposition of reticular fibrin-like substance occur in liver. Part epithelial cell degeneration of renal tubule appears in medulla and juncture of it and cortex in kidney. Spleen shows germinal center increase and focal necrosis of its cap of splenic corpuscle. The number of folliculus lymphaticus and the volume of germinal center in lymph node and intestinal mucosa-related lymphatic tissue rise. The level of the pathological changes in liver and spleen in female animal is more serious than male animal. Conclusion liver, spleen, kidney, lymph nod and intestinal mucosa-related lymphatic tissue can be damaged by trolamine iv.