細(xì)胞色素P450（CYP450）是體內(nèi)參與藥物代謝的重要酶系，其活性在受到誘導(dǎo)或抑制后將干擾藥物的作用。植物成分普遍存在于食物與藥物中，與CYP450的相互作用將產(chǎn)生廣泛影響?？偨Y(jié)近年來植物成分與細(xì)胞色素P450的7個亞型CYP1A2、CYP2A6、CYP2C9、CYP2C19、CYP2D6、CYP2E1、CYP3A4相互作用的研究結(jié)果，為臨床上合理用藥提供參考。

Cytochrome P450 is a kind of important enzyme for the metabolism of drugs and could interfere the effects of drugs after the activity is inhibited or induced. The phytochemicals are widespread in food and drugs, and have a lot of chances to interact with drugs on cytochrome P450. This kind of interaction has wide-ranging impacts. Therefore, this article reviews the interaction between phytochemicals and seven major isoforms of cytochrome P450 (CYP1A2, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4) and provides the valuable information for the rational use of related medicines in clinic.

國家重大新藥創(chuàng)制專項(xiàng)（2011ZX09401-009；2010ZX09401-307-1-1）