目的 探討阿托伐他汀致不良反應(yīng)（ADR）的一般規(guī)律與特點(diǎn)。方法 對福建省長樂市醫(yī)院2008年1月—2012年6月上報(bào)的阿托伐他汀所致10例ADR報(bào)告表進(jìn)行統(tǒng)計(jì)、分析。結(jié)果 阿托伐他汀引起的ADR中，女性7例，男性3例。發(fā)生次數(shù)最多為心肌、心內(nèi)膜、心包及瓣膜損害3次（17.65%），肝膽系統(tǒng)損害3次（17.65%）、全身性損害2次（11.76%）、中樞及外周神經(jīng)系統(tǒng)損害2次（11.76%）、胃腸系統(tǒng)損害2次（11.76%）。結(jié)論 臨床上應(yīng)加強(qiáng)阿托伐他汀應(yīng)用的監(jiān)測，以減少不良反應(yīng)的發(fā)生。

Objective To explore the general rules and characteristics of the adverse reactions(ADR) caused by Atorvastatin. Methods Ten cases of ADR reduced by Atorvastatin in Fujian Changle Hospital from January 2008 to June 2012 were reported and statistically analyzed. Results In the 10 cases of ADR reduced by Atorvastatin (female 7 cases and male 3 cases),. the myocardial, endocardial, pericardial and valvular damage and the hepatobiliary system damage were most frequently occurred (for three times, 17.65%, respectively), followed by the systemic damage (twice, 11.76%), the central and peripheral nervous system damage (twice, 11.76%), and the gastrointestinal system damage (twice, 11.76%). Conclusion The clinical application of Atorvastatin should be monitored , in order to reduce the occurrence of ADR.