雷公藤甲素為雷公藤的主要活性成分之一，也是雷公藤片、雷公藤多苷片等制劑的主要有效成分。它具有抗炎、抗腫瘤、免疫調(diào)節(jié)等藥理作用，是熱點(diǎn)研究的天然活性化合物。但是，雷公藤甲素的副作用在很大程度上影響了其在臨床上的應(yīng)用，其中對(duì)生殖系統(tǒng)的毒性及抗生育作用尤為明顯，特別是對(duì)雄性生殖系統(tǒng)的影響。綜述了雷公藤甲素對(duì)男性睪丸、附睪和精子等，以及對(duì)女性生殖系統(tǒng)的損害及作用機(jī)制，并建議系統(tǒng)開(kāi)展配伍減毒增效的研究，實(shí)現(xiàn)對(duì)配伍雷公藤甲素安全窗口的拓寬優(yōu)化，為安全有效地應(yīng)用于臨床提供有力依據(jù)。

Triptolide is one of the main active constituents in Tripterygium wilfordii. It is the main effective component of T. wilfordii preparations. Triptolide has the anti-inflammatory, antitumor, and immunomodulatory effects, which is a natural active drug attracting research focus. However, to a large extent, the side effects of triptolide limitted the clinical applications. The toxicities on the reproductive system and the antifertility effect are particularly obvious, especially the male reproductive system. In this paper, the information was collected and analyzed to summarize the damage mechanisms of triptolide on male testes, epididymis, sperm, and female reproductive system as well. Besides, the further studies should be carried out on the detoxification and enhancement action, so as to broaden and optimize the security window of triptolide, and to provide a powerful basis for its safety and effect on the clinical application.

福建省自然科學(xué)基金項(xiàng)目（2013J01367）；福建省科技重大專項(xiàng)（2009YZ0001-1-3）；福建省省屬公益類科研院所基本科研專項(xiàng)（2011R1034-3）；福建省衛(wèi)生廳青年科研基金項(xiàng)目（2012-1-14）