目的 研究牛蒡苷的抗炎和解熱作用，為牛蒡苷及牛蒡子的臨床應(yīng)用提供依據(jù)。方法 應(yīng)用小鼠耳廓腫脹模型、大鼠肉芽腫和弗氏完全佐劑模型觀察牛蒡苷對急慢性炎癥的影響，采用大腸桿菌內(nèi)毒素發(fā)熱家兔模型觀察牛蒡苷的解熱作用。結(jié)果 牛蒡苷在60、120、240 mg/kg劑量下顯著減輕二甲苯所致小鼠耳廓腫脹，減少大鼠肉芽組織增生，明顯降低發(fā)熱家兔體溫，但并不改善佐劑性關(guān)節(jié)炎大鼠足關(guān)節(jié)腫脹程度。結(jié)論 牛蒡苷具有良好的抗急性炎癥和解熱作用。

Objective The anti-inflammatory and antipyretic activities of arctiin in animals were investigated to guide the clinical applications of arctiin and Arctii Fructus. Methods The anti-inflammatory activity was assessed using the inflammation models induced by dimethylbenzene, croton oil and Freund's complete adjuvant in mice or rats. The antipyretic effect was estimated using the rabbit fever model elicited by Escherichia coli endotoxin. Results Arctiin could significantly alleviate the ear swelling of mice, the proliferation of granulation tissue of rats, and fever of rabbits, but could not ameliorate the paw edema induced by Freund's complete adjuvant in rats. Conclusion Arctiin possesses the anti-inflammatory effect on the acute inflammation and has the antipyretic activity.

國家自然科學(xué)基金資助項目（81360094，81260110）；寧夏科技支撐計劃項目（寧科計字[2012]17）