目的 建立生理鹽水注射液中雙酚A（BPA）殘留量的測定方法。方法 采用氣相色譜-三重四級桿（GC-TQ-MS/MS）聯(lián)用技術(shù)，測定了5批生理鹽水注射液中BPA的殘留量，每批平行測定6次，且每次分別在5、10、20 μg/kg 3個添加水平下進(jìn)行加樣回收，每水平分別測定3次。結(jié)果 所測5批生理鹽水注射液中BPA質(zhì)量分?jǐn)?shù)分別為27.01、11.80、15.73、22.28、9.03 μg/kg；RSD分別為2.3%、4.2%、3.2%、4.4%、1.9%；平均加樣回收率在79.9%～99.3%，RSD均小于4.1%。BPA在10～200 μg/L內(nèi)呈良好的線性關(guān)系，檢測限為1.25 μg/kg。結(jié)論 該法簡便快速、靈敏性高，可用于生理鹽水注射液中BPA殘留量的測定。

Objective To establish a GC-TQ-MS/MS method for the determination of bisphenol A (BPA) in physiological saline injection (PSI). Methods The determination of BPA remaining in five batches of PSI with six parallel tests for each batch. Spiked recovery rates were determined in added levels at 5, 10, and 20 μg/kg for three times in each level. Results The contents of BPA in five batches of PSI were 27.01, 11.80, 15.73, 22.28, and 9.03 μg/kg, respectively, with RSD values of 2.3%, 4.2%, 3.2%, 4.4%, and 1.9%. The average recovery rates were between 79.9% and 99.3% with RSD values less than 4.1%. There was a good liner relationship in the range of 10—200 μg/L for BPA and the limit of detection (LOD) was 1.25 μg/kg. Conclusion The method is simple, rapid, accurate and repeatable, and can be used to measure the content of BPA in PSI with high sensitivity.

江蘇出入境檢驗檢疫局項目（2011KJ48）；鎮(zhèn)江市科技支撐計劃（SH2012010）