[關(guān)鍵詞]
[摘要]
目的 研究止血靈膠囊的止血、縮宮、抗炎、補(bǔ)血等藥理作用。方法 采用相應(yīng)的藥理學(xué)模型研究止血靈膠囊在止血、縮宮、抗炎、補(bǔ)血方面的作用。結(jié)果 止血靈膠囊對大鼠子宮平滑肌有明顯的興奮作用,顯著增加大鼠子宮平滑肌收縮幅度和活動力;能明顯縮短小鼠出血時(shí)間及大鼠凝血酶時(shí)間;對大鼠血小板數(shù)和血小板聚集功能有一定的提高作用趨勢;對二甲苯致小鼠耳廓腫脹有明顯的抑制作用;明顯抑制小鼠腹腔毛細(xì)血管通透性增高和大鼠棉球肉芽腫的形成;對雌性失血性“血虛”小鼠的血紅蛋白含量及紅細(xì)胞數(shù)目有一定的提高作用。結(jié)論 止血靈膠囊具有縮宮、止血、消炎三重功效,并有一定補(bǔ)血的作用。
[Key word]
[Abstract]
Objective To study the pharmacological effects of Zhixueling Capsule on hemostasis, uterine contraction, anti- inflammation, and enriching blood, and to explore its mechanisms. Methods Corresponding pharmacological animal models were established to investigate the uterine contraction, and hemostatic, anti-inflammatory, and blood enriching effects of Zhixueling Capsule. Results Zhixueling Capsule could excite uterine smooth muscle of rats significantly, and increase the twitch amplitude and activity of uteri in vitro. It was observed that Zhixueling Capsule could shorten the bleeding time in mice and thrombin time in rats significantly, as well as increase the platelet amount and platelet aggregation in rats. It was also observed that Zhixueling Capsule could significantly inhibit the ear edema induced by xylene and the increase of abdominal capillary permeability induced by acetic acid in mice, as well as the granulation swelling induce by cotton in rats. The results showed that Zhixueling Capsule could improve the content of hemoglobin and red blood cells in lost blood anemia female mice. Conclusion Zhixueling Capsule has the effects of hemostasis, uterine contraction, anti-inflammation, and enriching blood.
[中圖分類號]
[基金項(xiàng)目]