目的 了解上海市松江區(qū)中心醫(yī)院住院藥房抗生素的使用情況，為臨床合理用藥提供參考。方法 統(tǒng)計(jì)2010—2012年住院藥房抗生素的消耗金額、用藥總劑量、限定日劑量（DDD）、用藥天數(shù)、用藥頻率（DDDS）、日均費(fèi)用（DDC）、藥物利用指數(shù)（DUI）以及抗生素使用率、抗生素使用強(qiáng)度（AUD）等，分析臨床應(yīng)用情況。結(jié)果 3年來上海市松江區(qū)中心醫(yī)院抗生素使用率和使用強(qiáng)度都超過了衛(wèi)生部的相關(guān)標(biāo)準(zhǔn)，但呈現(xiàn)下降趨勢。結(jié)論 住院藥房對(duì)抗生素的用藥基本合理，但個(gè)別藥物DUI＞1，存在不合理使用情況，應(yīng)進(jìn)一步加強(qiáng)對(duì)抗生素使用的監(jiān)督管理，防止少數(shù)抗生素的濫用。

Objective To analyze the clinical use of antibiotics from inpatient pharmacy in Songjiang Central Hospital of Shanghai, and to provide the evidence for clinically reasonable use of antibiotics. Methods By calculating the following parameters between 2010 and 2012, including the cost of antibiotics from inpatient pharmacy, total amount of antibiotics, defined daily dose (DDD), duration of antibiotics use, DDDS, DDC, drug utilization index (DUI), frequency of antibiotics use for each patient, antibiotics use density (AUD), etc, the clinical use of antibiotics was analyzed. Results The frequency and amount of antibiotic used in the past 3 years were significantly larger than the requirements of the standard of Ministry of Public Health; However, the trends of antibiotics use were decreased from 2010 to 2012. Conclusion The antibiotics use from inpatient pharmacy remains unreasonable, and even the DUI for certain antibiotics is larger than 1. Therefore, the supervision of clinical use of antibiotics should be emphasized in the future to avoid the overuse of antibiotics.