中藥是一個復雜的巨系統(tǒng)，其藥效是其中多種化學成分相互作用所產生的綜合效果。中藥藥動學研究經歷了從“單成分、單靶點”到“多成分、多靶點”的轉變，相應的藥動學評價模式也經歷了相似的發(fā)展過程，從最初針對單體成分的藥動學研究，到以單成分研究單味中藥及復方的藥動學，再到多組分整合藥動學，以及之后的以藥動學–藥效學結合模式評價復方藥動學。對以上中藥藥動學評價模式的發(fā)展進行了初步探討。

Chinese materia medica (CMM) is a complicated macrosystem, and the efficacy is synthetic by variety of chemical composition. The pharmacokinetic study of CMM transformed from “single component, single targets” to “multiple components, multiple targets”, and its evaluation mode transformed in a similar process: pharmacokinetic study aimed at monomer composition, pharmacokinetic study of single Chinese herb or compound prescription through single component, integrated pharmacokinetics of multicomponent, and uses of pharmacokinetics/pharmacodynamics binding mode to evaluate the pharmacokinetics of CMM, and this development process was discussed primarily in this article.