目的 比較生、熟大黃及其入下瘀血湯對(duì)熱結(jié)血瘀模型大鼠的血液流變學(xué)的影響，以闡釋生大黃瀉熱通便、熟大黃活血化瘀的炮制作用。方法 采用ig熱性中藥結(jié)合sc鹽酸腎上腺素的方法，復(fù)制大鼠熱結(jié)血瘀模型，再ig不同劑量的生、熟大黃以及生、熟大黃組成下瘀血湯，觀察對(duì)模型大鼠血液流變學(xué)的影響。結(jié)果 熟大黃各劑量組與等劑量的生大黃相比，其血液流變學(xué)的各項(xiàng)指標(biāo)檢測(cè)值均有所改變，其中熟大黃高劑量組全血黏度、紅細(xì)胞剛性指數(shù)與變形指數(shù)（TK）與生大黃相比，差異具有顯著性（P＜0.01）；熟大黃復(fù)方組與等劑量生大黃復(fù)方組比較，其血液流變學(xué)的各項(xiàng)指標(biāo)也有明顯改變。結(jié)論 熟大黃的活血化瘀作用強(qiáng)于生大黃，大黃炮制后可增強(qiáng)其活血化瘀作用。

Objective To clarify the effects of raw and stewed rhubarb and Xiayuxue Decoction on hemorheological parameters in rats with heat accumulation of blood stasis by comparing the influence of them on purgative and promoting blood circulation. Methods The rat model with heat accumulation of blood stasis was established by ig administration with heat Chinese medicine and sc injection with adrenaline hydrochloride. At the same time, raw and stewed rhubarb and Xiayuxue Decoction at different doses were given. Then the hemorheological parameters of the rats were observed and compared. Results Compared with the same dose of raw rhubarb, the stewed rhubarb changed each hemorheological parameter and there were extremely significant differences in whole blood viscosity, erythrocyte rigidity index, and erythrocyte deformation index （TK）between raw and stewed rhubarb at high dose (P < 0.01). There were differences in hemorheological parameters of complex prescription with raw and stewed rhubarb at the same dose. Conclusion The efficiency of stewed rhubarb on promoting blood circulation to remove blood stasis is definitely better than that of raw rhubarb, and processing of the raw rhubarb could strengthen the effect of promoting blood circulation to remove blood stasis .

中醫(yī)藥行業(yè)科研專項(xiàng)（20110700710）