目的 探討抗癆復(fù)肝膠囊對(duì)實(shí)驗(yàn)動(dòng)物的止咳祛痰、保肝復(fù)肝作用。方法 采用氨水引咳法、氣管酚紅排泄法觀察抗癆復(fù)肝膠囊的止咳祛痰作用；采用異煙肼和利福平制作肝損傷模型，檢測肝臟指數(shù)及AST和ALT的含量，并觀察各組小鼠肝組織的病理學(xué)改變。結(jié)果 抗癆復(fù)肝膠囊能夠顯著減少小鼠的咳嗽次數(shù)、增加小鼠氣道酚紅排泄量；各給藥組小鼠肝臟指數(shù)和血清中ALT和AST水平顯著降低，與模型組比較具有統(tǒng)計(jì)學(xué)意義（P＜0.05、0.01），給藥組小鼠肝組織損傷有明顯的逆轉(zhuǎn)。結(jié)論 抗癆復(fù)肝膠囊有顯著的止咳祛痰作用，對(duì)利福平和異煙肼所致的肝組織損傷也有顯著的保護(hù)作用。

Objective To investigate the effect such as antitussive, expectorant, protecting hepatic function of Kanglao Fugan Capsule. Methods The antitussive and expectorant effect on cough model of mice were investigated by ammonia liquor and phenol red excretion. As hepatic injury model by isoniazid and rifampicin, the liver indexes of mice, AST and ALT levels, were detected,. At same time we observed the pathological changes in liver tissues of mice. Results Kanglao Fugan Ｃapsule could significantly reduce the frequency of cough of mice and increase the airway phenol red excretion. Compared with the model group, the liver indexes of mice, ALT and AST content in serum of mice in drug group were significantly decreased,with statistical significance (P < 0.05 or P < 0.01). The liver tissue injury of drug treated mice was significantly reversed. Conclusion Kanglao Fugan Capsule not only has the antitussive and expectorant effect, but also has the significant protection on liver injury induced by rifampin and isoniazid.