目的 考察不同吸收促進劑對芍藥苷在大鼠十二指腸吸收過程的影響，篩選最佳吸收促進劑。方法 利用大鼠在體單向腸灌流模型，采用HPLC法測定灌流液中芍藥苷含量，分別考察聚山梨酯80、羥丙基-β-環(huán)糊精、癸酸鈉、去氧膽酸鈉和當(dāng)歸提取物對吸收的促進作用。結(jié)果 羥丙基-β-環(huán)糊精和當(dāng)歸提取物能顯著提高芍藥苷的腸道吸收速率，其次是癸酸鈉和聚山梨酯80，而去氧膽酸鈉則沒有作用。結(jié)論 羥丙基-β-環(huán)糊精和當(dāng)歸提取物可作為芍藥苷口服制劑的吸收促進劑使用，中藥當(dāng)歸配伍芍藥使用是合理、有效的。

Objective To investigate the effects of different enhancers on the transport properties of paeoniflorin in rat duodenum, in order to select the best absorption enhancers. Methods In situ single-pass intestinal perfusion model was performed to study the absorption of paeoniflorin. The concentration of paeoniflorin was determined by HPLC. Tween 80, HP-β-CD, sodium caprate，sodium deoxycholate, and angelica extract were chosen as the enhancers. Results HP-β-CD and angelica extract significantly improved the rate of duodenal absorption of paeoniflorin, followed by sodium caprate and Tween 80, and sodium deoxycholate had no effect. Conclusion HP-β-CD and angelica extract would be used as enhancers in oral paeoniflorin formulations. Angelica and peony pairs are reasonable and effective.

廣東省科技計劃項目（2011B031700060）；廣東藥學(xué)院大學(xué)生創(chuàng)新訓(xùn)練項目（1057313015）