目的 考察不同塑料外包裝材料對(duì)復(fù)方西瓜霜滴眼液中主要成分含量的影響。方法 采用常溫留樣和加速試驗(yàn)法（40 ℃±2 ℃），用高效液相色譜法（測(cè)定瓜氨酸含量）和氣相色譜法（測(cè)定天然冰片、乙醇的含量），分別考察復(fù)方西瓜霜滴眼液在低密度聚乙烯（LDPE）、聚丙烯（PP）和聚酯（PET）3種塑料外包裝材料中存放0、1、2、3、6個(gè)月后瓜氨酸、天然冰片和乙醇的含量。結(jié)果 PET材料的藥用滴眼劑瓶密封性最好，PP材料的次之，LDPE材料的密封性相對(duì)最差，不利于復(fù)方滴眼液的保存。結(jié)論 復(fù)方西瓜霜滴眼液適合選擇密封性相對(duì)較好的聚酯、聚丙烯材料作為外包裝材料。

Objective To determine the effects of different plastic packaging materials on the main components in Compound Mirabilitum Praeparatum Eye Drops. Methods The retention samples were put at the room temperature (25 ℃±2 ℃) and in the acceleration test (40 ℃±2 ℃). The contents of citrulline, natural borneol, and ethanol in Compound Mirabilitum Praeparatum Eye Drops packaged respectively by low density polyethylene (LDPE), polypropylene (PP), and polyester (PET), which were stored for 0－3, and 6 months, were determined by HPLC and GC. Results The bottle sealing by PET is best, followed by PP. LDPE is the worst and not conducive to be preserved in it. Conclusion PET and PP are suitable to use as the packages of Compound Mirabilitum Praeparatum Eye Drops.