薏苡仁提取物及其有效成分對多種高血糖模型動物和高血脂肥胖模型動物均呈現(xiàn)出降糖、降脂作用，并能對抗高血糖、高血脂引起的代謝綜合征及其并發(fā)癥（包括氧化應(yīng)激反應(yīng)、動脈粥樣硬化、腦缺血和免疫功能異常）。其有效成分包括薏苡仁多糖、羥基不飽和脂肪酸和多酚化合物，作用機(jī)制與提高葡萄糖激酶活性、促進(jìn)組織對葡萄糖的利用、改善胰島素抵抗和糖代謝紊亂，通過激活Nrf2/ARE依賴的細(xì)胞保護(hù)基因，對抗氧化應(yīng)激性細(xì)胞損傷等有關(guān)。

Coicis Semen extract and its active constituents show hypoglycemic and hypolipidemic effects on various models of diabetic and hyperlipidemic obesity animals, and also effective in antagonism to metabolism syndrome induced by hyperglycemia and hyperlipidemia and its complications (oxidative stress, artherosclerosis, cerebral ischemia, and abnormal immune function). Its active constituents include coixans, hydroxyl unsaturated fatty acid, and polyphenols. Its active mechanisms are relative to the enhancement of glucose utilization and glucokinase activity in tissue, improve the disorder of glycometabolism and insulin resistance, and to antagonize oxidative stress-induced cell injury by activation of Nrf2/ARE-depentent cytoprotective genes, and so on. Research progress in Coicis Semen and its active constituents with the function against metabolism syndrome is reviewed.

國家自然科學(xué)基金資助項(xiàng)目（39370838）