目的 觀察固腎1號對膜性腎小球腎炎的影響，并探討其可能的作用機(jī)制。方法 采用家兔C-BSA膜性腎炎模型和大鼠主動Heymann模型，觀察固腎1號對尿蛋白定量、血液生化、腎臟系數(shù)、腎臟病理的影響。結(jié)果 固腎1號能顯著降低（24 h）尿蛋白定量，降低血清尿素氮（BUN）、肌酐（Cr）水平，升高血清總蛋白（Tp）、白蛋白（Alb）水平，并能降低腎臟系數(shù)，減輕腎臟病變。結(jié)論 固腎1號對膜性腎小球腎炎有明顯的防治作用。

Objective To investigate the effect of Gushen 1 on the membranous glomerulonephritis and detect its possible mechanisms. Methods C-BSA membranous nephritis of rabbitss induced by administration of an exogenous cationic antigen and active Heymann nephritis of rats induced by immunization with renal cortex were used to observe the therapeutic effect of Gushen 1 on urine protein, blood biochemistry, kidney index, and kidney pathology. Results Gushen 1 could significantly reduce 24 h surine protein, serum urea nitrogen, and serum creatinine, while increase the levels of serum total protein and albumin. A significant reducing of renal index and improvement of kidney pathology were observed in the group of Gushen1compared to the model group. Conclusion It is obvious that Gushen 1 could improve the kidney pathology and be used for the treatment of membranous glomerulonephritis.