2-·的清除能力。結(jié)果 在50~200 mg/L Alpine-TLBP 能顯著增加正常小鼠的胸腺和脾臟的質(zhì)量,提高臟器指數(shù),且明顯增強小鼠腹腔巨噬細(xì)胞吞噬百分率和吞噬指數(shù);且在50~500 μg/mL具有較強的清除·OH 和O2-·的能力,IC50 分別為142.2 μg/mL 和203.2 μg/mL,呈劑量相關(guān)性。結(jié)論 Alpine-TLBP 能增強正常小鼠的免疫功能,且具有較強的清除·OH 和O2-·的能力。;Objective To study the effects of Alpine Trametes lactinea Berk. polysaccharide (Alpine-TLBP) on immunoloregulation and anti-oxidation in vitro. Methods The immune functions were investigated by measuring thymus and spleen indices, celiac macrophage phagocytic index, and phagocytic rate from normal mice which were ig administered with Alpine-TLBP (50, 100, and 200 mg/kg) everyday, respectively; The clearing effect of Alpine-TLBP on hydroxyl radical was measured by salicylic acid capture method; The clearing effect of Alpine-TLBP on superoxide anion free radical was measured by pyrogallol auto oxidation method. Results Alpine-TLBP among 50—200 mg/L could significantly enhance thymus and spleen weight, viscera index, and celiac macrophage phagocytosis; Alpine-TLBP had a significant effect on clearing hydroxyl radical and superoxide anion radical, Alpine-TLBP among 50—500 μg/mL has dose-response relationship on the effect of clearing hydroxyl radical and superoxide anion radical, and the IC50 were 142.2 μg/mL and 203.2 μg/mL, respectively. Conclusion Alpine-TLBP can enhance normal mouse immunological function, and has strong ability of clearing hydroxyl radical and superoxide anion radical."/>

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首頁 > 過刊瀏覽>2014年第37卷第5期 >2014,37(5):409-412. DOI:10.7501/j.issn.1674-6376.2014.05.006
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高寒乳白栓菌多糖免疫調(diào)節(jié)及體外抗氧化活性研究

Effects of Alpine Trametes lactinea Berk. polysaccharide on immunoloregulation and anti-oxidation in vitro

發(fā)布日期:2014-10-13
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