目的 觀察壯骨1 號方的鎮(zhèn)痛抗炎作用，為臨床研究提供科學(xué)依據(jù)。方法 采用小鼠熱板、醋酸扭體兩種鎮(zhèn)痛實驗方法，觀察壯骨1 號方的鎮(zhèn)痛作用；采用小鼠二甲苯耳腫模型和大鼠棉球肉芽腫模型，觀察壯骨1 號方的抗炎作用。結(jié)果 壯骨1 號方能有效地緩解由外界熱刺激和化學(xué)性刺激引起的機體的疼痛，具有較好的鎮(zhèn)痛作用，尤以高、中劑量效果顯著；能有效的降低小鼠、大鼠的急性炎癥和慢性炎癥的發(fā)生，具有較好的抗炎效果。結(jié)論 壯骨1 號方具有顯著的鎮(zhèn)痛和抗炎效果。

Objective To observe the main pharmacodynamics of Zhuanggu No.1 Prescription. Methods Using the methods of mice hot plate and mice acetic acid-induced writhing, the analgesic effect of Zhuanggu No.1 Prescription was observed; Using the methods of xylene-induced ear inflammation in mice and granuloma swelling induced by cotton ball in rats, the effects of anti-inflammation was observed. Results Zhuanggu No.1 Prescription had good analgesic effect, and could relieve the pain induced by thermostimulation and chemical stimulation, especially at high and middle doses. In anti-inflammatory tests, Zhuanggu No.1 Prescription had good anti-inflammatory effect, and could reduce the acute and chronic inflammation in mice. Conclusion Zhuanggu No.1 Prescription has significant analgesic and anti-Inflammatory effects.

國家“重大新藥創(chuàng)制”科技重大專項（2011ZX09201-201-21）