目的 了解甲硝唑致出血性膀胱炎的一般情況和特點(diǎn)，為臨床合理用藥提供參考。方法 以“甲硝唑”并含“出血性膀胱炎”為主要檢索詞，對(duì)1990 年—2013 年中國(guó)期刊全文數(shù)據(jù)庫(kù)、維普及萬(wàn)方數(shù)據(jù)庫(kù)文獻(xiàn)進(jìn)行檢索，收集甲硝唑致出血性膀胱炎的10 例病例報(bào)道，探討不良反應(yīng)發(fā)生的特點(diǎn)，并提出合理用藥建議。結(jié)果 5 例患者為女性，5 例男性，平均年齡（37.70±5.10）歲，在使用甲硝唑2～3 d 后發(fā)生出血性膀胱炎，甲硝唑的劑量為0.6～1.4 g/d，停藥3～7 d 后出血性膀胱炎明顯好轉(zhuǎn)，沒(méi)有死亡病例。結(jié)論 嚴(yán)格按照藥品說(shuō)明書(shū)用藥、加強(qiáng)用藥監(jiān)測(cè)、對(duì)發(fā)生的反應(yīng)及時(shí)處理是防控甲硝唑致出血性膀胱炎有效措施。

Objective To clarify the general situation and characteristics of Metronidazole-induced hemorrhagic cystitis so as, to provide the reference for clinical rational drug use. Methods "Metronidazole" and contain "hemorrhagic cystitis" as the main search term, for 1990-2013 China Academic Journal, VIP and WanFangDATA literature retrieval, the Metronidazole-induced hemorrhagic cystitis 10 cases reports were collected, its features of side effect were explored and the suggestion for rational use of drugs was put forward. Results Five patients were female and five male, their mean age was (37.70 ± 5.10), hemorrhagic cystitis occurred in the use of Metronidazole 1-3 d, metronidazole dose was 0.6-1.4 g/d, hemorrhagic cystitis was significantly improved after 3-7 d, withdrawal, there was no death. Conclusion In strict accordance with the package insert medication, the monitoring of medication should be strengthened. The effective measures is to timely treat the advers drug reaction occurried, in order to prevent the Metronidazole-induced hemorrhagic cystitis.