目的 觀察注射用紅花黃色素治療不穩(wěn)定型心絞痛的臨床效果。方法 80例患者隨機(jī)分為紅花黃色素治療組和對(duì)照組。對(duì)照組常規(guī)給予硝酸脂類、鈣通道阻滯劑、β受體阻滯劑及阿司匹林治療。治療組在此基礎(chǔ)上加用注射用紅花黃色素100 mg加入0.9%氯化鈉注射液250 mL中靜滴,每日1次,14 d為一療程。觀察治療前、后臨床癥狀,每日心絞痛發(fā)作次數(shù),持續(xù)時(shí)間,疼痛程度,心率、血壓變化情況、硝酸甘油片的消耗量。結(jié)果 兩組治療后血脂情況都有所改善,但紅花黃色素治療組效果要優(yōu)于對(duì)照組(P<0.01)。紅花黃色素治療組和對(duì)照組患者臨床有效率分別為97.00%和86.00%,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 紅花黃色素治療冠心痛心絞痛療效確切。

Objective To evaluate the efficacy of Safflor Yellow Injection for the treatment of angina pectoris with coronary heart disease (CHD). Methods Eighty patients were divided into control group, which was given nitric acid lipid, calcium channel blockers, beta blockers and aspirin therapy and safflor yellow group. There are 40 patients in each group. Besides conventional therapy, the patients in safflor yellow group received the iv injection of 100 mg safflor yellow in 250 mL 0.9% sodium chloride injection. Clinical signs were observed before and after the treatment, such as daily episodes of angina pectoris, continuous time, the degree of pain, changes in heart rate and blood pressure, and consumption of nitroglycerin tablets. Results After the treatment, blood lipid in both groups had been improved, but the effect in safflower yellow pigment group is superior to the control group (P<0.01). The total effective rates of safflor yellow group and control group were 97% and 86% respectively (P<0.05﹚. Conclusion The treatment with Safflor Yellow Injection for angina pectoris with coronary heart disease is safe and effective.