女貞子提取物及其活性成分齊墩果酸、熊果酸、紅景天苷等對去卵巢大小鼠,雌性老齡大鼠均具有抗骨質(zhì)疏松作用,能抗糖皮質(zhì)激素引起的或糖尿病并發(fā)的骨質(zhì)疏松以及膠原性關(guān)節(jié)炎大鼠的骨質(zhì)破壞。它們的作用機(jī)制可能是通過(1)促進(jìn)成骨細(xì)胞分化,抑制基質(zhì)金屬蛋白酶表達(dá),阻滯破骨細(xì)胞激活;(2)促進(jìn)活性維生素D₃生物合成以及維生素D受體和鈣結(jié)合蛋白表達(dá),促進(jìn)腸鈣吸收,抑制尿鈣排泄,提高骨密度,產(chǎn)生抗骨質(zhì)疏松的防治作用。綜述了女貞子及其活性成分抗骨質(zhì)疏松作用的研究進(jìn)展,為新藥研發(fā)提供依據(jù)。

Ligustrum lucidum extract and its active components (oleanolic acid, ursolic acid, salidroside, etc.) have anti-osteoporotic effects: antagonism to osteoporosis in ovariectomized rats or mice, aged female rats, and glucocorticoid- or diabetes-induced osteoporosis, and bone destruction in collagen-induced arthritis. They could increase bone mineral density and produce preventive and therapeutic effects for osteoporosis, by promotion of osteoblast differentiation, inhibition of the expression of matrix metalloproteinases, and obstruction of osteoclast activation; by promoting the biosynthesis of active vitamin D₃, and the expression of vitamin D receptor and calcium-binding proteins, enhancing the intestinal calcium absorption, and suppressing urinary calcium excretion. This paper reviews the researchprogressin theanti-osteoporosisofLigustrum lucidumanditsactivecomponents to provide the basis for research and development new drug.