目的 探討瑞舒伐他汀致不良反應(yīng)的一般情況和特點(diǎn),為臨床合理用藥提供參考。方法 以“瑞舒伐他汀”為主要檢索詞,對2000年1月—2014年9月中國期刊全文數(shù)據(jù)庫進(jìn)行檢索,收集瑞舒伐他汀致不良反應(yīng)的12例病例報道,探討其特點(diǎn),并提出合理用藥建議。結(jié)果 8例患者為男性,4例女性,平均年齡(70.08±1.78)歲,瑞舒伐他汀的劑量為5~10 mg/d,不良反應(yīng)一般在使用瑞舒伐他汀5 d后發(fā)生,主要表現(xiàn)為肝損害和橫紋肌溶解。停藥并進(jìn)行相應(yīng)治療1周后不良反應(yīng)明顯好轉(zhuǎn),出現(xiàn)死亡病例1例。結(jié)論 嚴(yán)格按照藥品說明書用藥、加強(qiáng)用藥監(jiān)測、對發(fā)生的不良反應(yīng)及時處理是防控瑞舒伐他汀致不良反應(yīng)有效措施。

Objective To investigate the general rules and characteristics of adverse effects induced by Rosuvastatin and, to provide the reference for clinical rational use of drug. Methods “Rosuvastatin” as the main key words to search in Chinese periodical full text database in January 2000—September 2014. Report on 12 cases with Rosuvastatin-induced adverse reactions were collected, the characteristics were discussed, and some reasonable recommendations were put forward. Results Eight patients were male and 4 were female, mean age was (70.08±1.78), Rosuvastatin dose was 5－10 mg/d, the adverse reactions generally occurred in the use of Rosuvastatin 5 d, mainly for liver damage and rhabdomyolysis. While the adverse reaction was improved by withdrawing drug then by corresponding treatment for 1 week. One death case appeared. Conclusion In strict accordance with the use of drug instruction, strengthening the drug monitoring, the treatment of reaction in time is the effective measures for the prevention and control of Rosuvastatin adverse reactions.