冬蟲(chóng)夏草為我國(guó)傳統(tǒng)名貴中藥,具有抗腫瘤、降血脂、免疫調(diào)節(jié)、祛痰、平喘、抗心律失常、保護(hù)肝腎功能等多種藥理學(xué)作用。隨著對(duì)冬蟲(chóng)夏草免疫機(jī)制的深入研究,為其作為抗腫瘤藥物提供了有力證據(jù)。綜述了冬蟲(chóng)夏草及其活性成分對(duì)黑色素瘤、甲狀腺癌、胃癌、肺癌、乳腺癌等多種腫瘤的抑制作用,主要從吞噬細(xì)胞、自然殺傷細(xì)胞、樹(shù)突狀細(xì)胞、B/T淋巴細(xì)胞以及促進(jìn)細(xì)胞因子的分泌等幾個(gè)方面探討冬蟲(chóng)夏草對(duì)其免疫活性的影響。其免疫調(diào)節(jié)的作用機(jī)制主要通過(guò)T淋巴細(xì)胞介導(dǎo)的細(xì)胞免疫應(yīng)答和B/T淋巴細(xì)胞介導(dǎo)的體液免疫應(yīng)答。

Cordyceps sinensis as a traditional Chinese herbal medicine, has a variety of pharmacological effects of anti-tumor, reducing blood lipid, immune regulation, eliminating phlegm, relieving asthma, anti-arrhythmic, protecting liver and kidney, and so on.With the further research of immunological mechanism, C. sinensis has been considered as a potential candidate of anti-tumor drug. In this paper, amount of experiments data and clinical trials indicated the chemical constituents from C. sinensis have the significant inhibition on a variety of tumors, such as melanoma, thyroid cancer, gastric cancer, lung cancer, breast cancer, and other tumors. The strong anti-tumor activities support the interpretation of immunoregulatory mechanism of C. sinensis, which could activate T-lymphocyte cellular immune response and B/T lymphocyte-mediated humoral immune response. Our paper summarized the immune responses of the components from C. sinensis by macrophages, nature killer cells, dendritic cells, B/T lymphocytes and cytokines.

北京市中醫(yī)藥科技項(xiàng)目-“冬蟲(chóng)夏草抗菌肽類物質(zhì)的分離鑒定及其免疫調(diào)節(jié)作用的機(jī)制研究”(JJ2013-52)