9/L 值顯著高于對(duì)照組(P<0.05)。治療前兩組患者的WBC 水平差異不顯著,治療第7、14、30 天 G-CSF 組患者的WBC 水平顯著高于對(duì)照組(P<0.05)。治療前兩組患者的CD3+、CD4+、CD8+、CD4+/CD8+值比較差異不顯著,治療第30 天G-CSF 組患者的CD8+細(xì)胞顯著低于對(duì)照組(P<0.05),CD4+/CD8+值顯著高于對(duì)照組(P<0.05)。G-CSF 組患者的發(fā)熱時(shí)間(7.5±3.6)d、感染持續(xù)時(shí)間(13.4±5.6)d 顯著低于對(duì)照組(P<0.05)。治療6 個(gè)月后,G-CSF 組的總有效率78.38%顯著高于對(duì)照組的52.00%(P<0.05),治療過(guò)程中G-CSF 組有2 例患者死亡(5.41%),低于對(duì)照組的4 例(16%),但差異不具有統(tǒng)計(jì)學(xué)意義。結(jié)論 常規(guī)治療基礎(chǔ)上加用粒細(xì)胞集落因子治療急性再生障礙性貧血對(duì)于改善患者的血常規(guī)指標(biāo)、緩解臨床癥狀、提高治療效果具有顯著意義。;Objective To investigate the clinical effect of granulocyte colony-stimulating factor (G-CSF) in the treatment of acute aplastic anemia. Methods A retrospective study of 62 cases of acute aplastic anemia treatment of patients in General Hospital of Beijing Military Region from 2008 to 2014 as performed. The patients were divided into G-CSF treatment group (37 cases) and control group (25 cases), the patients in control group received conventional therapy of androgen binding, and the patients in G-CSF group were added with the use of G-CSF treatment. The peripheral targets at different time after treatment, T cell subsets targets, and clinical efficacy between the two groups were compared. Results The Hb and PLT values in two groups before treatment were detected without significant difference (P> 0.05), and after G-CSF treatment group Hb 74.5 ± 15.3 (g/L), PLT 27.4 ± 8.8 (109/L) was significantly higher than in the control group (P <0.05). WBC level between the two groups before treatment, the patient was not significant (P> 0.05), after treatment, the level of the first WBC 7, 14, 30 d G-CSF group were significantly higher than the control (P <0.05). Treatment groups were pre-CD3+, CD4+, CD8+, CD4+/CD8+ value difference was not significant (P> 0.05), after treatment, G-CSF group of patients with CD8 + cells were 0.30±0.04 was significantly lower than the control group (P <0.05), CD4+/CD8+ value of 0.83±0.04 was significantly higher (P <0.05). G-CSF group of patients with fever 7.5±3.6 (d), infection duration 13.4±5.6 (d) was significantly lower than the control group (P <0.05). After 6 months of treatment, the total G-CSF group 78.38% significantly higher than the 52.00% (P <0.05) the efficiency of the treatment process, G-CSF group 2 patients died (5.41%) than the control 4 cases (16%) group but the difference was not statistically significant (P> 0.05). Conclusion Conventional therapy based on the use of granulocyte colony-factor treatment of acute aplastic anemia patients to improve blood indicators, relieve symptoms, improve treatment has significant meaning."/>

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首頁(yè) > 過(guò)刊瀏覽>2015年第38卷第6期 >2015,38(6):656-659. DOI:10.7501/j.issn.1674-6376.2015.06.015
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粒細(xì)胞集落因子治療急性再生障礙性貧血臨床價(jià)值

Clinical value of granulocyte colony-stimulating factor in treatment of acute aplastic anemia

發(fā)布日期:2015-12-08
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