目的 評價孟魯司特鈉在呼吸道合胞病毒(RSV)感染的兒童毛細支氣管炎治療中的應(yīng)用價值。方法 120 例確診RSV 感染性毛細支氣管炎的患兒隨機分為2 組,對照組和治療組各60 例。對照組采用常規(guī)療法,治療組在對照組基礎(chǔ)上加用孟魯司特鈉5 mg/次、口服1 次/d,比較治療7 d 后兩組的療效及預(yù)后。結(jié)果 治療組患兒的咳嗽消失時間、喘憋消失時間、呼吸困難消失時間、肺部濕羅音消失時間、住院時間均顯著的低于對照組(P< 0.01)。治療第3、7 天兩組患兒的尿白三烯E4(LTE4)、血清半胱氨酸白三烯(CysLTS)、血氧飽和度(TcSaO2)均較治療前顯著好轉(zhuǎn)(P< 0.05),且治療組優(yōu)于對照組(P< 0.05)。治療第7 天治療組患兒的臨床有效率為95%,顯著高于對照組的83.33%(P< 0.05);治療組的復(fù)發(fā)率為3.33%,顯著低于對照組的13.33%(P< 0.05)。結(jié)論 孟魯司特鈉結(jié)合常規(guī)療法治療RSV 毛細支氣管炎具有縮短治療時間、盡快緩解臨床癥狀,改善LTE4、CysLTS 炎癥因子的作用,從而有效提高臨床療效。

Objective To evaluate the application value of montelukast sodium in the treatment of bronchiolitis infection induced by respiratory syncytial virus (RSV). Methods The confirmed RSV infection bronchiolitis children (120 cases) were randomly divided into control (n = 60) and treatment (n = 60) groups. The patients in the control group were given conventional therapy, while the patients in the treatment group were administered with montelukast sodium, po 5 mg/time, 1 time/d, after 5 d the treatment effects of two groups were compared. Results The disappeared time of cough, wheezing disappearance time, breathing difficulties disappearance time and lung wet rales disappearance time, hospitalization time in treatment group were significantly lower than those of normal group (P<0.01) in children. LTE4, serum CysLTS, and TcSaO2 were significantly improved in days 3 and 7 in two groups after treatment, compared with those before treatment (P<0.05), and the treatment group was significantly better than the conventional group (P<0.05). The clinical effective rate of treatment group was 95%, significantly higher than that of the conventional group (83.33%, P<0.05), and the recurrence rate was 3.33% in the treatment group was significantly lower than that in the conventional group (13.33%, P<0.05). Conclusion Montelukast sodium combined with conventional therapy in the treatment of RSV bronchiolitis has shorter treatment time, relieves the clinical symptoms as soon as possible, and improves LTE4, CysLTS role of cytokines, which can effectively improve the clinical efficacy.