南嶺蕘花Wikstroemia indica 為瑞香科蕘花屬植物,其根及根皮為常用中草藥了哥王。近年來化學研究顯示其根及根皮中含有大量的黃酮類成分以及木脂素、香豆素、甾醇等化合物;藥理研究發(fā)現(xiàn)了哥王有顯著的抗腫瘤作用,因此成為新藥研發(fā)的熱點。對文獻中有關南嶺蕘花的化學成分和抗腫瘤藥理活性研究進展進行綜述,為進一步深入研究提供參考。

Wikstroemia indica, belonging to family Thymelaeaceae and genus Wikstroemia Endl., was widely distributed in southern China, and its root and root bark were common traditional Chinese herbal medicine. So far large quantity of flavonoids had been isolated from the plant, together with other types of active principles, such as lignans, coumarins, sterols, and others. In recent years, the plant had the significant antitumor effect. Therfore, it becomes the hotspot of research and development. This paper reviews on the chemical constituents and antitumor activities of Wikstroemia indica in the literature, and provides a reference for the further research.

國家自然基金青年項目(81303267,81302744);中國博士后基金資助項目(2014M550149,2015T80226)