目的 研究如意珍寶片對血管性癡呆(VD)大鼠的保護作用。方法 采用改良雙側(cè)頸總動脈永久性結(jié)扎法制備大鼠VD模型,以Y迷宮為學(xué)習(xí)記憶評價指標,并測定VD大鼠腦內(nèi)多巴胺(DA)、去甲腎上腺素(NE)、5-羥色胺(5-HT)3種單胺類神經(jīng)遞質(zhì)水平。結(jié)果 如意珍寶片能顯著的增加Y迷宮的正確次數(shù)和提高腦內(nèi)3種單胺類神經(jīng)遞質(zhì)水平。結(jié)論 如意珍寶片能提高VD大鼠學(xué)習(xí)記憶能力,升高腦內(nèi)單胺類神經(jīng)遞質(zhì)水平,從而改善大腦皮層的興奮性,激活腦損傷后的學(xué)習(xí)記憶過程。

Objective To investigate the protective effects of Ruyi Zhenbao Tablet (RZT) on vascular dementia in rats. Methods The permanent bilateral common carotid artery ligation method was used to establish the rat model of vascular dementia (VD). The learning and memory abilities were evaluated by Y maze. Besides, the levels of three monoamine neurotransmitters including dopamine (DA), norepinephrine (NE), and 5-hydroxytryptamine (5-HT) within rat brain were also determined. Results The correct number of Y maze and the brain levels of three monoamine neurotransmitters can be significantly enhanced in the VD models treated by RZT compared to other controls. Conclusion RZT was able to enhance the learning and memory abilities of VD rats and protect the monoamine neurotransmitters, as a result the cerebral cortex excitability of the VD rats was improved and thereafter, the learning and memory procedure was exited in the rats with brain injury.