目的 探討仙靈骨葆膠囊治療絕經(jīng)后骨質(zhì)疏松(PMOP)性Colles骨折的臨床療效。方法 124例絕經(jīng)后輕創(chuàng)傷性穩(wěn)定型Colles骨折女患者隨機(jī)分成治療組與對(duì)照組,每組62例。兩組給予相同的閉合手法復(fù)位、腕自由位小夾板前臂固定,治療組po仙靈骨葆膠囊3粒/次,對(duì)照組po三七片3片/次,均2次/d,連服12周。于治療后次日和第4、8、12周抽血檢測(cè)血清堿性磷酸酶(ALP),治療第6周拆除夾板拍攝X片觀察骨痂生長(zhǎng)情況,第12周觀察殘余腫脹、腕關(guān)節(jié)活動(dòng)恢復(fù)等情況,比較兩組的療效及不良反應(yīng)。結(jié)果 兩組患者血清ALP、骨愈合X線評(píng)分和優(yōu)良率、殘余腫脹、腕關(guān)節(jié)功能恢復(fù)等情況比較,治療組優(yōu)于對(duì)照組,兩組差異均有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 仙靈骨葆膠囊治療PMOP性Colles骨折的臨床效果顯著,可促進(jìn)骨痂生長(zhǎng),安全性高,不良反應(yīng)少,能較早進(jìn)入功能鍛煉,獲得較為滿意的功能恢復(fù),可作為PMOP骨折治療的理想選擇。

Objective To evaluate the clinical effects of Xianling Gubao Capsules (XGC) in treatment of postmenopausal women osteoporotic Colles fracture. Methods Postmenopausal women (124 cases) with mild traumatic stable Colles fractures were randomly divided into control group and treatment group, 62 cases in each group. The two groups were given the same closed manipulative reduction and mall splint forearm fixation (not fixed wrist joint). The patients in control group received oral Sanqi Tablets, the patients in treatment group were orally given XGC, 2 times a day, 3 pills each time, continuously for 12 weeks. On the day after reduction, 4, 8 and 12 weeks were detected the serum alkaline phosphatase (ALP), 6 weeks removed splint, and shoot X-tablets, understanding the growth state of the bone scab. In the 12th week, the degree of residual swelling and wrist joint activity recovery were observed. The treatment effect and untoward reactions of the two groups were compared. Results The serum ALP, bone healing X-ray score, excellent rate of bone healing, residual swelling, and wrist joint function recovery in traetment group were better than ontrol group, the difference was statistically significant (P < 0.05). Conclusion The clinical effect of XGC in the treatment of postmenopausal women with osteoporosis of the trauma type Colles fracture is significant, can promote callus growth and high safety, and adverse drug reactions occurred less. Patients can enter the functional exercise early and get a more satisfactory functional recovery. Therefore, it can be used as an ideal choice for the treatment of osteoporotic fracture in postmenopausal women.